Ehrlich ascites tumor cells produce a transforming growth factor-β (TGFβ)-like activity but lack receptors with TGFβ-binding capacity
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http://hdl.handle.net/10045/9728
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Camp Dublin Core | Valor | Idioma |
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dc.contributor | Genética Humana y de Mamíferos | en |
dc.contributor.author | Elexpuru Artetxe, Ana | - |
dc.contributor.author | Martín-Nieto, José | - |
dc.contributor.author | Jiménez Martínez, Amparo | - |
dc.contributor.author | Gómez Torres, Carmen | - |
dc.contributor.author | Villalobo Polo, Antonio | - |
dc.contributor.other | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | en |
dc.contributor.other | Instituto de Investigaciones Biomédicas | en |
dc.date.accessioned | 2009-02-23T09:16:43Z | - |
dc.date.available | 2009-02-23T09:16:43Z | - |
dc.date.created | 1996-08-06 | - |
dc.date.issued | 1997-05 | - |
dc.identifier.citation | ELEXPURU ARTETXE, Ana, et al. "Ehrlich ascites tumor cells produce a transforming growth factor-β (TGFβ)-like activity but lack receptors with TGFβ-binding capacity". Molecular and Cellular Biochemistry. Vol. 170, No. 1-2 (May 1997). ISSN 0300-8177, pp. 153-162 | en |
dc.identifier.issn | 0300-8177 (Print) | - |
dc.identifier.issn | 1573-4919 (Online) | - |
dc.identifier.uri | http://hdl.handle.net/10045/9728 | - |
dc.description.abstract | Ehrlich ascites tumor cells incorporate [methyl-3H]thymidine into DNA independently of exogenous growth factors or fetal calf serum. Using an acid/ethanol extraction procedure we have obtained from these tumor cells a fraction that induces both the proliferation and the formation of cell foci by Swiss 3T3 mouse fibroblasts in the presence of insulin; inhibits the proliferation of Mv1Lu mink lung epithelial cells; and stimulates the growth of NRK rat kidney fibroblasts in soft-agar in the presence of epidermal growth factor. An antibody against transforming growth factor-β (TGFβ) prevents both the tumor extract-induced proliferation of Swiss 3T3 fibroblasts and the tumor extract-induced proliferative arrest of Mv1Lu cells. The tumor cells secrete a TGFβ-like activity to the extracellular medium in a partially-activated form. However, authentic TGFβ does not affect their proliferation, and no TGFβ receptors were detected using [125I]TGFβ as a ligand. Therefore, the absence of TGFβ receptors with ligand-binding capacity in these tumor cells may bypass the negative control that this factor exerts on the proliferation of their normal cell counterparts. | en |
dc.description.sponsorship | This work was supported by Grants to A.V. from the Comisión Interministerial de Ciencia y Tecnología (SAF392/93 and SAF96-35) and from the Dirección General de Investigación Científica y Técnica (PR94-343). | en |
dc.language | eng | en |
dc.publisher | Kluwer Academic Publishers | en |
dc.rights | The original publication is available at www.springerlink.com | en |
dc.subject | Transforming growth factor-β receptors | en |
dc.subject | Ehrlich ascites tumor cells | en |
dc.subject.other | Genética | en |
dc.title | Ehrlich ascites tumor cells produce a transforming growth factor-β (TGFβ)-like activity but lack receptors with TGFβ-binding capacity | en |
dc.type | info:eu-repo/semantics/article | en |
dc.peerreviewed | si | en |
dc.identifier.doi | 10.1023/A:1006809604193 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1023/A:1006809604193 | - |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | - |
Apareix a la col·lecció: | INV - GHM - Artículos de Revistas |
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Elexpuru 1997 Mol Cell Bioch.pdf | Versión final (acceso restringido) | 122,7 kB | Adobe PDF | Obrir Sol·licitar una còpia |
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