Relationship between Serum Dioxin-Like Polychlorinated Biphenyls and Post-Testicular Maturation in Human Sperm
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Título: | Relationship between Serum Dioxin-Like Polychlorinated Biphenyls and Post-Testicular Maturation in Human Sperm |
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Autor/es: | Paul, Raiza | Moltó Berenguer, Julia | Ortuño García, Nuria | Romero, Alejandro | Bezos, Carlos | Aizpurua, Jon | Gómez-Torres, María José |
Grupo/s de investigación o GITE: | Residuos, Energía, Medio Ambiente y Nanotecnología (REMAN) | Biotecnología |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Ingeniería Química | Universidad de Alicante. Departamento de Biotecnología |
Palabras clave: | Male fertility | Human serum | DL-PCBs | Semen parameters | Endocrine disruptors |
Área/s de conocimiento: | Ingeniería Química | Biología Celular |
Fecha de publicación: | 10-jul-2017 |
Editor: | Elsevier |
Cita bibliográfica: | Reproductive Toxicology. 2017, 73: 312-321. doi:10.1016/j.reprotox.2017.07.004 |
Resumen: | The relationship between dioxin-like polychlorinated biphenyl (DL˗PCB) levels in serum and semen parameters were investigated. Our case-control included two groups of patients. Total concentrations of PCBs were significantly higher in the low semen quality (n = 24) than in the normal semen quality (n = 26) group. A significant negative correlation was found between PCB 126 and viability in men with low semen quality, while PCBs 77 and 81 were positively correlated with morphology, and PCB 118, mono-ortho and total DL-PCBs were positively correlated with volume. In the normal semen quality group, PCB 189 and 118 were negatively correlated with sperm motility and volume, respectively. In addition, positive significant correlations were found between PCB 77, 23 and total non-ortho PCBs with regard to morphology. Our findings suggest that sperm motility, viability, volume and morphology are parameters sensitive to alteration by exposure to DL-PCBs, although PCB effects on spermatogenesis were not of clinical significance. |
Patrocinador/es: | This study was supported by Cátedra Human Fertility from the University of Alicante, CTQ2013-41006-R grant from the Ministerio Economía y Competitividad, and PROMETEOII/2014/007 grant from the Valencian Community Government (Spain). |
URI: | http://hdl.handle.net/10045/68068 |
ISSN: | 0890-6238 (Print) | 1873-1708 (Online) |
DOI: | 10.1016/j.reprotox.2017.07.004 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2017 Elsevier Inc. |
Revisión científica: | si |
Versión del editor: | http://dx.doi.org/10.1016/j.reprotox.2017.07.004 |
Aparece en las colecciones: | INV - Grupo de Inmunología - Artículos de Revistas INV - REMAN - Artículos de Revistas INV - GIDBT - Artículos de Revistas INV - I4CE - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
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2017_Paul_etal_ReprodToxic_accepted.pdf | Accepted Manuscript (acceso abierto) | 815,09 kB | Adobe PDF | Abrir Vista previa |
2017_Paul_etal_ReprodToxic_final.pdf | Versión final (acceso restringido) | 518,97 kB | Adobe PDF | Abrir Solicitar una copia |
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