On the Specific Adsorption of 7-methylguanine on Au(111) Surfaces for the Electroanalytical Sensing of Methylation Levels
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Title: | On the Specific Adsorption of 7-methylguanine on Au(111) Surfaces for the Electroanalytical Sensing of Methylation Levels |
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Authors: | Brotons Cuevas, Ariadna | Feliu, Juan M. | Montiel, Vicente | Iniesta, Jesus | Vidal-Iglesias, Francisco J. | Solla-Gullón, José |
Research Group/s: | Electroquímica Aplicada y Electrocatálisis | Electroquímica de Superficies |
Center, Department or Service: | Universidad de Alicante. Departamento de Química Física | Universidad de Alicante. Instituto Universitario de Electroquímica |
Keywords: | Gas chromatography | Liquid chromatography | Analytical methods |
Knowledge Area: | Química Física |
Issue Date: | 4-Nov-2015 |
Publisher: | iMedPub |
Citation: | Insights in Analytical Electrochemistry. 2015, 1(1): 7 |
Abstract: | The electrochemical determination of 7-methylguanine (7-mG) may result of interest because its presence can serve as probe of cytosine methylation of which is known as the most relevant epigenetic modification of DNA. This work explores the electrochemical response of 7-mG on different gold surfaces, both poly and single crystalline surfaces (Au (110), Au (111) and Au (100)). The results show that the adsorption-desorption process of the 7-mG is sensitive to the surface structure of the gold electrodes. Particularly, 7-mG adsorption-desorption profile on a Au (111) electrode exhibits some specific contributions which are found sensitive to the 7-mG concentration and, thereby could allow its quantification. These results may shed light on the future development of an electrochemical sensor for the diagnosis of the methylation degree in DNA. |
Sponsor: | Authors would like to acknowledge funding obtained through the Spanish Ministry of Science and Innovation (MICINN) CTQ2013-48280-C3-3-R project. |
URI: | http://hdl.handle.net/10045/52417 |
ISSN: | 2470-9867 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Rights: | © Copyright iMedPub. Licensed under a Creative Commons Attribution License |
Peer Review: | si |
Publisher version: | http://electroanalytical.imedpub.com/archive.php |
Appears in Collections: | INV - EQSUP - Artículos de Revistas INV - LEQA - Artículos de Revistas |
Files in This Item:
File | Description | Size | Format | |
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2015_Brotons_etal_IAE.pdf | 2,18 MB | Adobe PDF | Open Preview | |
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