Highest Plasma Phenylalanine Levels in (Very) Premature Infants on Intravenous Feeding; A Need for Concern

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Títol: Highest Plasma Phenylalanine Levels in (Very) Premature Infants on Intravenous Feeding; A Need for Concern
Autors: Cortés Castell, Ernesto | Sánchez-González, Pablo | Palazón Bru, Antonio | Bosch-Giménez, Vicente | Manero, Herminia | Juste-Ruiz, Mercedes | Rizo-Baeza, Mercedes | Gil Guillén, Vicente
Grups d'investigació o GITE: Salud y Cuidados en Grupos Vulnerables (SACU) | Enfermería y Cultura de los Cuidados
Centre, Departament o Servei: Universidad de Alicante. Departamento de Enfermería
Paraules clau: Blood levels | Phenylalanine | Intravenous feeding | Premature infants
Àrees de coneixement: Enfermería
Data de publicació: 21-de setembre-2015
Editor: Public Library of Science (PLoS)
Citació bibliogràfica: Cortés-Castell E, Sánchez-González P, Palazón-Bru A, Bosch-Giménez V, Manero-Soler H, Juste-Ruiz M, et al. (2015) Highest Plasma Phenylalanine Levels in (Very) Premature Infants on Intravenous Feeding; A Need for Concern. PLoS ONE 10(9): e0138532. doi:10.1371/journal.pone.0138532
Resum: Objective. To analyse the association in newborns between blood levels of phenylalanine and feeding method and gestational age. Study Design. This observational, cross-sectional study included a sample of 11,829 infants between 2008 and 2013 in a Spanish region. Data were recorded on phenylalanine values, feeding method [breast, formula, mixed (breast plus formula), or partial or fully intravenous feeding], gestational age in weeks (<32, 32–37, ≥37), gender and days since birth at the moment of blood collection. Outcomes were [phenylalanine] and [phenylalanine] ≥95th percentile. Associations were analysed using multivariate models [linear (means difference) and logistic regression (adjusted odds ratios)]. Results. Higher phenylalanine values were associated with lower gestational age (p<0.001) and with intravenous feeding (p<0.001). Conclusion. The degree of prematurity and intravenous feeding influenced the plasma concentration of phenylalanine in the newborn. Caution should be taken in [phenylalanine] for newborns with intravenous feeding, monitoring them carefully. Very preterm infants given the recommended amount of amino acids should also be strictly monitored. These findings should be taken into consideration and call for adapting the amounts to the needs of the infant.
URI: http://hdl.handle.net/10045/49693
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0138532
Idioma: eng
Tipus: info:eu-repo/semantics/article
Drets: © 2015 Cortés-Castell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Revisió científica: si
Versió de l'editor: http://dx.doi.org/10.1371/journal.pone.0138532
Apareix a la col·lecció: INV - EYCC - Artículos de Revistas
INV - SACU - Artículos de Revistas

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