Homologation of heterocycles by a sequential reductive opening lithiation-electrophilic substitution-cyclization

Abstract

The development of new methodologies for the conversion of simple reactants into more complex compounds is the main goal of synthetic organic chemistry. For instance, transforming readily available small heterocycles into much less common medium-sized rings would be of great interest, because many biological active compounds possess medium-sized heterocyclic units in their structure. Thus, synthetic approaches to heterocyclic compounds require the development of methodology for easily repeatable heterocycle homologation and multicarbon ring expansion.