Evaluation of a solid-phase enzyme immunoassay in the diagnosis of syphilis
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http://hdl.handle.net/10045/17824
Title: | Evaluation of a solid-phase enzyme immunoassay in the diagnosis of syphilis |
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Authors: | Borobio, M.V. | Álvarez-Dardet, Carlos | Gallardo, R.M. |
Research Group/s: | Salud Pública |
Center, Department or Service: | Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia |
Keywords: | ELISA | VDLR | Syphilis |
Knowledge Area: | Medicina Preventiva y Salud Pública |
Issue Date: | 1985 |
Publisher: | Churchill Livingstone |
Citation: | BOROBIO, M.V.; ÁLVAREZ-DARDET DÍAZ, Carlos; GALLARDO, R.M. "Evaluation of a solid-phase enzyme immunoassay in the diagnosis of syphilis". European Journal of Sexually Transmitted Diseases. 2 (1985). ISSN 0261-5622, pp. 231-233 |
Abstract: | A solid phase enzyme-linked immuno sorbent assay (ELISA), the antigen being bound to the surface of ferrous metal beads, was evaluated as either a diagnostic or a confirmative test for syphilis by comparison with the Venereal Disease Research Laboratory (VDRL) and the fluorescent treponemal antibody absorption (FTA-abs) tests in two groups of` population: healthy people and syphilitic patients. The sensitivity of the ELISA test was found to be 75%, the specificity 98.1%. There were no statistically significant differences as to accuracy (sensitivity and specificity) between ELISA test and the VDRL test (p<0.05). The ELISA test therefore does not represent an improvement in the first line syphilis diagnosis when compared with the classical VDRL test. ELISA was less reactive than the FTA-abs test in all the stages of the disease. Its only advantage is easier performance by automation. |
URI: | http://hdl.handle.net/10045/17824 |
ISSN: | 0261-5622 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Peer Review: | si |
Appears in Collections: | INV - SP - Artículos de Revistas Institucional - IUIEG - Publicaciones |
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Evaluation of a solid phase enzyme inmunoassay in the diagnosis of syphilis.pdf | 205,81 kB | Adobe PDF | Open Preview | |
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