Simulation of daily soft multifocal contact lenses using SimVis Gekko: from in-vitro and computational characterization to clinical validation

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Title: Simulation of daily soft multifocal contact lenses using SimVis Gekko: from in-vitro and computational characterization to clinical validation
Authors: Esteban-Ibañez, Eduardo | Montagud-Martínez, Diego | Sawides, Lucie | Zaytouny, Amal | de Castro, Alberto | Sisó-Fuertes, Irene | Barcala, Xoana | Piñero, David P. | Furlan, Walter D. | Dorronsoro, Carlos | Gambra, Enrique
Research Group/s: Grupo de Óptica y Percepción Visual (GOPV)
Center, Department or Service: Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía
Keywords: Multifocal contact lenses | Presbyopia | Visual simulator | SimVis Gekko
Issue Date: 13-Apr-2024
Publisher: Springer Nature
Citation: Scientific Reports. 2024, 14:8592. https://doi.org/10.1038/s41598-024-59178-1
Abstract: Multifocal contact lenses (MCLs) are one of the solutions to correct presbyopia, but their adoption is not widespread. To address this situation, visual simulators can be used to refine the adaptation process. This study aims to obtain accurate simulations for a visual simulator (SimVis Gekko; 2EyesVision) of daily soft MCL designs from four manufacturers. In-vitro characterization of these MCLs—several powers and additions- was obtained using NIMO TR-1504. From the averaged relative power profiles across powers, phase maps were reconstructed and the Through-Focus Visual Strehl metric was calculated for each MCL design. The SimVis Gekko simulation corresponding to each MCL design was obtained computationally and bench-validated. Finally, the MCL simulations were clinically validated involving presbyopic patients. The clinical validation results show a good agreement between the SimVis Gekko simulations and the real MCLs for through-focus visual acuity (TF-VA) curves and VA at three real distances. All MCL designs showed a partial correlation higher than 0.90 and a Root Mean Square Error below 0.07 logMAR between the TF-VA of simulations and Real MCLs across subjects. The validity of the simulation approach using SimVis Gekko and in-vitro measurements was confirmed in this study, opening the possibility to accelerate the adaptation of MCLs.
Sponsor: This work was supported by multiple funding sources, including the Madrid Regional Government under the Industrial Doctorate Grant (IND2020/BMD-17442) to E.E-I. and A.Z., the Ministerio de Universidades, Spain (funded by the European Union Next Generation EU) under the Margarita Salas Grant to D.M.-M. and the Ministerio de Ciencia e Innovación, Spain, under Ayudas a proyectos de colaboración publico-privada (CPP2021-008388) to A.d.C. and C.D., Torres Quevedo Grant (PTQ2021-011963) to I.S.-F. and Ramon y Cajal Grant (RYC2021-033355-I) to L.S.
URI: http://hdl.handle.net/10045/142181
ISSN: 2045-2322
DOI: 10.1038/s41598-024-59178-1
Language: eng
Type: info:eu-repo/semantics/article
Rights: © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Peer Review: si
Publisher version: https://doi.org/10.1038/s41598-024-59178-1
Appears in Collections:INV - GOPV - Artículos de Revistas

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