Engineering Proteins for PEDOT Dispersions: A New Horizon for Highly Mixed Ionic-Electronic Biocompatible Conducting Materials
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http://hdl.handle.net/10045/139471
Títol: | Engineering Proteins for PEDOT Dispersions: A New Horizon for Highly Mixed Ionic-Electronic Biocompatible Conducting Materials |
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Autors: | Dominguez-Alfaro, Antonio | Casado, Nerea | Fernandez, Maxence | Garcia-Esnaola, Andrea | Calvo, Javier | Mantione, Daniele | Calvo, M. Reyes | Cortajarena, Aitziber L. |
Grups d'investigació o GITE: | Física de la Materia Condensada |
Centre, Departament o Servei: | Universidad de Alicante. Departamento de Física Aplicada |
Paraules clau: | Bioelectronics | Conductive biomaterials | Consensus tetratricopeptide repeat (CTPR) | Engineered proteins | Inkjet printing | Mixed conductors | PEDOT | Self-assembly |
Data de publicació: | 21-de desembre-2023 |
Editor: | Wiley-VCH GmbH |
Citació bibliogràfica: | Small. 2023. https://doi.org/10.1002/smll.202307536 |
Resum: | Poly (3,4-ethylenedioxythiophene) (PEDOT) doped with polystyrene sulfonate (PSS) is the most used conducting polymer from energy to biomedical applications. Despite its exceptional properties, there is a need for developing new materials that can improve some of its inherent limitations, e.g., biocompatibility. In this context, doping PEDOT is propose with a robust recombinant protein with tunable properties, the consensus tetratricopeptide repeated protein (CTPR). The doping consists of an oxidative polymerization, where the PEDOT chains are stabilized by the negative charges of the CTPR protein. CTPR proteins are evaluated with three different lengths (3, 10, and 20 identical CTPR units) and optimized varied synthetic conditions. These findings revealed higher doping rate and oxidized state of the PEDOT chains when doped with the smallest scaffold (CTPR3). These PEDOT:CTPR hybrids possess ionic and electronic conductivity. Notably, PEDOT:CTPR3 displayed an electronic conductivity of 0.016 S cm−1, higher than any other reported protein-doped PEDOT. This result places PEDOT:CTPR3 at the level of PEDOT-biopolymer hybrids, and brings it closer in performance to PEDOT:PSS gold standard. Furthermore, PEDOT:CTPR3 dispersion is successfully optimized for inkjet printing, preserving its electroactivity properties after printing. This approach opens the door to the use of these novel hybrids for bioelectronics. |
Patrocinadors: | A.L.C. acknowledges support by the Agencia Estatal de Investigación Grant PID2019-111649RB-I00 funded by MCIN/AEI/ 10.13039/501100011033; Grant PDC- 2022- 133345- I00, andGrant TED2021-131641B-C41 funded by MCIN/AEI/ 10.13039/501100011033 and by the “European Union NextGenerationEU/PRTR. A.L.C. acknowledges support by the European Research Council Grant Agreement No. 648071 (ProNano). M.R.C. acknowledges support from Agencia Estatal de Investigación Grant TED2021-131641B-C43 funded by MCIN/AEI/ 10.13039/501100011033 and by the ”European Union NextGenerationEU/PRTR and from the Generalitat Valenciana through the Plan Gen-T of Excellence, grant CideGenT2018004. A.L.C. and M.R.C. acknowledge support by European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No. 964593 (eProt). |
URI: | http://hdl.handle.net/10045/139471 |
ISSN: | 1613-6810 (Print) | 1613-6829 (Online) |
DOI: | 10.1002/smll.202307536 |
Idioma: | eng |
Tipus: | info:eu-repo/semantics/article |
Drets: | © 2023 The Authors. Small published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Revisió científica: | si |
Versió de l'editor: | https://doi.org/10.1002/smll.202307536 |
Apareix a la col·lecció: | Investigacions finançades per la UE INV - Física de la Materia Condensada - Artículos de Revistas |
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Arxiu | Descripció | Tamany | Format | |
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Dominguez‐Alfaro_etal_2023_Small.pdf | 8,44 MB | Adobe PDF | Obrir Vista prèvia | |
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