Gradual morphogenesis of retinal neurons in the peripheral retinal margin of adult monkeys and humans
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http://hdl.handle.net/10045/13679
Títol: | Gradual morphogenesis of retinal neurons in the peripheral retinal margin of adult monkeys and humans |
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Autors: | Martínez Navarrete, Gema Concepción | Angulo Jerez, Antonia | Martín-Nieto, José | Cuenca, Nicolás |
Grups d'investigació o GITE: | Genética Humana y de Mamíferos | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) |
Centre, Departament o Servei: | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía |
Paraules clau: | Neuronal differentiation | Ciliary body | Photoreceptors | Retinal progenitors | Stem cells | Primates |
Àrees de coneixement: | Biología celular | Genética |
Data de publicació: | 6-d’octubre-2008 |
Editor: | Wiley-Liss, Inc. |
Citació bibliogràfica: | MARTÍNEZ NAVARRETE, Gema C., et al. "Gradual morphogenesis of retinal neurons in the peripheral retinal margin of adult monkeys and humans". The Journal of Comparative Neurology. Vol. 511, No. 4 (2008). ISSN 0021-9967, pp. 557-580 |
Resum: | The adult mammalian retina has been for long considered to lack neurogenerative capacity. However, retinal stem/progenitor cells which can originate retinal neurons in vitro have been recently reported in the ciliary body of adult mammals. Here we have explored the possibility of retinal neurogenesis occurring in vivo in adult monkeys and humans. We have found the presence of cells expressing molecular markers of neural and retinal progenitors in the non-laminated retinal margin and ciliary body pars plana of mature primates. By means of imunohistochemistry and electron microscopy we have also observed photoreceptors and other retinal cell types in different stages of morphological differentiation along the peripheral retinal margin. These findings allow us to extend to primates the idea of neurogenesis aimed at retinal cell turnover throughout life. |
Patrocinadors: | Grant sponsor: Ministerio de Educación y Ciencia; Grant number: BFU2006-00957/BFI; Grant sponsor: Ministerio de Sanidad y Consumo; Grant number: RETICS RD07/0062/0012; Grant sponsor: ONCE; Grant sponsor: Fundaluce (to N.C.); Grant sponsor: Generalitat Valenciana; Grant number: GV06/197 (to J.M.-N). |
URI: | http://hdl.handle.net/10045/13679 |
ISSN: | 0021-9967 (Print) | 1096-9861 (Online) |
DOI: | 10.1002/cne.21860 |
Idioma: | eng |
Tipus: | info:eu-repo/semantics/article |
Drets: | The definitive version is available at www3.interscience.wiley.com |
Revisió científica: | si |
Versió de l'editor: | http://dx.doi.org/10.1002/cne.21860 |
Apareix a la col·lecció: | INV - GHM - Artículos de Revistas INV - NEUROVIS - Artículos de Revistas |
Arxius per aquest ítem:
Arxiu | Descripció | Tamany | Format | |
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GCM-N 2008 JCN Ms.R4.pdf | Preprint (acceso libre) | 8,25 MB | Adobe PDF | Obrir Vista prèvia |
gradual_morphogenesis_final.pdf | Versión final (acceso restringido) | 5,55 MB | Adobe PDF | Obrir Sol·licitar una còpia |
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