Effect of an Immune-Boosting, Antioxidant and Anti-Inflammatory Food Supplement in Hospitalized COVID-19 Patients: A Prospective Randomized Pilot Study
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Title: | Effect of an Immune-Boosting, Antioxidant and Anti-Inflammatory Food Supplement in Hospitalized COVID-19 Patients: A Prospective Randomized Pilot Study |
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Authors: | Reino-Gelardo, Sandra | Palop-Cervera, Marta | Aparisi-Valero, Nieves | Espinosa-San Miguel, Ignacio | Lozano-Rodríguez, Noelia | Llop-Furquet, Gonzalo | Sanchis-Artero, Laura | Cortés Castell, Ernesto | Rizo-Baeza, Mercedes | Cortés-Rizo, Xavier |
Research Group/s: | Salud y Cuidados en Grupos Vulnerables (SACU) |
Center, Department or Service: | Universidad de Alicante. Departamento de Enfermería |
Keywords: | COVID-19 | Antioxidant | Anti-inflammatory | Food supplement |
Issue Date: | 1-Apr-2023 |
Publisher: | MDPI |
Citation: | Reino-Gelardo S, Palop-Cervera M, Aparisi-Valero N, Espinosa-San Miguel I, Lozano-Rodríguez N, Llop-Furquet G, Sanchis-Artero L, Cortés-Castell E, Rizo-Baeza M, Cortés-Rizo X. Effect of an Immune-Boosting, Antioxidant and Anti-Inflammatory Food Supplement in Hospitalized COVID-19 Patients: A Prospective Randomized Pilot Study. Nutrients. 2023; 15(7):1736. https://doi.org/10.3390/nu15071736 |
Abstract: | Background: COVID-19 disease is a serious global health problem. Few treatments have been shown to reduce mortality and accelerate time to recovery. The aim of this study was to evaluate the potential effect of a food supplement (probiotics, prebiotics, vitamin D, zinc and selenium) in patients admitted with COVID-19. Methods: A prospective randomized non-blinded clinical trial was conducted in a sample of 162 hospitalized patients diagnosed with COVID-19 recruited over eight months. All patients received standard treatment, but the intervention group (n = 67) was given one food supplement stick daily during their admission. After collecting the study variables, a statistical analysis was performed comparing the intervention and control groups and a multivariate analysis controlling for variables that could act as confounding factors. Results: ROC curve analysis with an area under the curve (AUC) value of 0.840 (p < 0.001; 95%CI: 0.741–0.939) of the food supplement administration vs. recovery indicated good predictive ability. Moreover, the intervention group had a shorter duration of digestive symptoms compared with the control group: 2.6 ± 1.3 vs. 4.3 ± 2.2 days (p = 0.001); patients with non-severe disease on chest X-ray had shorter hospital stays: 8.1 ± 3.9 vs. 11.6 ± 7.4 days (p = 0.007). Conclusions: In this trial, the administration of a food supplement (Gasteel Plus®) was shown to be a protective factor in the group of patients with severe COVID-19 and allowed early recovery from digestive symptoms and a shorter hospital stay in patients with a normal–mild–moderate chest X-ray at admission (ClinicalTrials.gov number, NCT04666116). |
URI: | http://hdl.handle.net/10045/133348 |
ISSN: | 2072-6643 |
DOI: | 10.3390/nu15071736 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Rights: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Peer Review: | si |
Publisher version: | https://doi.org/10.3390/nu15071736 |
Appears in Collections: | INV - SACU - Artículos de Revistas |
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Reino-Gelardo_etal_2023_Nutrients.pdf | 1,22 MB | Adobe PDF | Open Preview | |
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