Short-term high-fat feeding exacerbates degeneration in retinitis pigmentosa by promoting retinal oxidative stress and inflammation
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Title: | Short-term high-fat feeding exacerbates degeneration in retinitis pigmentosa by promoting retinal oxidative stress and inflammation |
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Authors: | Kutsyr, Oksana | Noailles, Agustina | Martínez Gil, Natalia | Maestre-Carballa, Lucia | Martinez-Garcia, Manuel | Maneu, Victoria | Cuenca, Nicolás | Lax, Pedro |
Research Group/s: | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) | Ecología Microbiana Molecular |
Center, Department or Service: | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía |
Keywords: | Retinal degeneration | Neurodegeneration | Cell death | Gut microbiome |
Knowledge Area: | Biología Celular | Fisiología | Microbiología | Farmacología |
Issue Date: | 19-Oct-2021 |
Publisher: | National Academy of Sciences |
Citation: | PNAS. 2021, 118(43): e2100566118. https://doi.org/10.1073/pnas.2100566118 |
Abstract: | A high-fat diet (HFD) can induce hyperglycemia and metabolic syndromes that, in turn, can trigger visual impairment. To evaluate the acute effects of HFD feeding on retinal degeneration, we assessed retinal function and morphology, inflammatory state, oxidative stress, and gut microbiome in dystrophic retinal degeneration 10 (rd10) mice, a model of retinitis pigmentosa, fed an HFD for 2 to 3 wk. Short-term HFD feeding impaired retinal responsiveness and visual acuity and enhanced photoreceptor degeneration, microglial cell activation, and Müller cell gliosis. HFD consumption also triggered the expression of inflammatory and oxidative markers in rd10 retinas. Finally, an HFD caused gut microbiome dysbiosis, increasing the abundance of potentially proinflammatory bacteria. Thus, HFD feeding drives the pathological processes of retinal degeneration by promoting oxidative stress and activating inflammatory-related pathways. Our findings suggest that consumption of an HFD could accelerate the progression of the disease in patients with retinal degenerative disorders. |
Sponsor: | This work was supported by grants from the Spanish Ministry of the Economy and Competitiveness (RTI2018-094248-B-I00), Spanish Ministry of Science and Innovation cofinanced by European Regional Development Fund (MICINN-FEDER PID2019-106230RB-I00), Instituto de Salud Carlos III co-financed by European Regional Development Fund (RETICS-FEDER-RD16/0008/0016), Asociación Retina Asturias (ASOCIACIONRETINA1-20I), Federación de Asociaciones de Retinosis Pigmentaria de España and Fundación Lucha Contra la Ceguera (FUNDALUCE18-01), and Generalitat Valenciana (PROMETEO/2021/024, IDIFEDER/2017/064). |
URI: | http://hdl.handle.net/10045/118819 |
ISSN: | 0027-8424 (Print) | 1091-6490 (Online) |
DOI: | 10.1073/pnas.2100566118 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Rights: | © 2021 National Academy of Sciences |
Peer Review: | si |
Publisher version: | https://doi.org/10.1073/pnas.2100566118 |
Appears in Collections: | INV - EMM - Artículos de Revistas INV - NEUROVIS - Artículos de Revistas |
Files in This Item:
File | Description | Size | Format | |
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Kutsyr_etal_2021_PNAS_final.pdf | 3,61 MB | Adobe PDF | Open Preview | |
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