Deep Eutectic Solvent as a Sustainable Medium for C–C Bond Formation Via Multicomponent Radical Conjugate Additions
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http://hdl.handle.net/10045/115588
| Títol: | Deep Eutectic Solvent as a Sustainable Medium for C–C Bond Formation Via Multicomponent Radical Conjugate Additions |
|---|---|
| Autors: | Saavedra, Beatriz | Ramón, Diego J. |
| Grups d'investigació o GITE: | Alternative Methodologies In Chemistry (AMIC) | Nuevos Materiales y Catalizadores (MATCAT) |
| Centre, Departament o Servei: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
| Paraules clau: | Deep eutectic solvent | Iron catalyst | Poly(methylhydrosiloxane) | Radical coupling | Sustainable synthesis |
| Àrees de coneixement: | Química Orgánica |
| Data de publicació: | 2-de juny-2021 |
| Editor: | American Chemical Society |
| Citació bibliogràfica: | ACS Sustainable Chemistry & Engineering. 2021, 9(23): 7941-7947. https://doi.org/10.1021/acssuschemeng.1c02193 |
| Resum: | Deep eutectic solvents (DESs) have been used for the first time as a sustainable medium in radical-mediated molecular organic synthetic protocols. This study reports an efficient protocol for the C–C bond formation through radical conjugate addition of simple olefins (di- and trisubstituted). An inexpensive and abundant iron catalyst [Fe(acac)3] together with nontoxic silane (poly(methylhydrosiloxane) (PMHS)) was employed, using choline chloride/ethylene glycol (1:2) as a solvent under air and mild reaction conditions. Different functional groups were well tolerated, and also, the reaction could be carried out on a gram scale with excellent yields. |
| Patrocinadors: | This work was supported by the University of Alicante (VIGROB-316FI) and the Spanish Ministerio de Economia, Industria y Competitividad (PGC2018-096616-B-100). B.S. thanks Generalitat Valenciana (ACIF/2017/211) for her fellowship. |
| URI: | http://hdl.handle.net/10045/115588 |
| ISSN: | 2168-0485 |
| DOI: | 10.1021/acssuschemeng.1c02193 |
| Idioma: | eng |
| Tipus: | info:eu-repo/semantics/article |
| Drets: | © 2021 American Chemical Society. Creative Commons Attribution 4.0 International License (CC BY 4.0) |
| Revisió científica: | si |
| Versió de l'editor: | https://doi.org/10.1021/acssuschemeng.1c02193 |
| Apareix a la col·lecció: | INV - AMIC - Artículos de Revistas INV - MATCAT - Artículos de Revistas |
Arxius per aquest ítem:
| Arxiu | Descripció | Tamany | Format | |
|---|---|---|---|---|
 Saavedra_Ramon_2021_ACSSustainableChem.pdf | 1,09 MB | Adobe PDF | Obrir Vista prèvia | |
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