Giani, Micaela, Garbayo, Inés, Vílchez, Carlos, Martínez-Espinosa, Rosa María Haloarchaeal Carotenoids: Healthy Novel Compounds from Extreme Environments Giani M, Garbayo I, Vílchez C, Martínez-Espinosa RM. Haloarchaeal Carotenoids: Healthy Novel Compounds from Extreme Environments. Marine Drugs. 2019; 17(9):524. doi:10.3390/md17090524 URI: http://hdl.handle.net/10045/95882 DOI: 10.3390/md17090524 ISSN: 1660-3397 Abstract: Haloarchaea are halophilic microorganisms belonging to the archaea domain that inhabit salty environments (mainly soils and water) all over the world. Most of the genera included in this group can produce carotenoids at significant concentrations (even wild-type strains). The major carotenoid produced by the cells is bacterioruberin (and its derivatives), which is only produced by this kind of microbes and few bacteria, like Micrococcus roseus. Nevertheless, the understanding of carotenoid metabolism in haloarchaea, its regulation, and the roles of carotenoid derivatives in this group of extreme microorganisms remains mostly unrevealed. Besides, potential biotechnological uses of haloarchaeal pigments are poorly explored. This work summarises what it has been described so far about carotenoids from haloarchaea and their production at mid- and large-scale, paying special attention to the most recent findings on the potential uses of haloarchaeal pigments in biomedicine. Keywords:Haloarchaea, Isoprenoid, Carotenoids, Bacterioruberin, Natural biosources, Microbial blooms, Antioxidant MDPI info:eu-repo/semantics/article