Alonso, Francisco, Riente Paiva, Paola, Yus, Miguel
Wittig-type olefination of alcohols promoted by nickel nanoparticles: synthesis of polymethoxylated and polyhydroxylated stilbenes
ALONSO VALDÉS, Francisco; RIENTE PAIVA, Paola; YUS ASTIZ, Miguel. "Wittig-type olefination of alcohols promoted by nickel nanoparticles: synthesis of polymethoxylated and polyhydroxylated stilbenes". European Journal of Organic Chemistry. Vol. 2009, Issue 34 (Oct. 2009). ISSN 1434-193X, pp. 6034-6042
URI: http://hdl.handle.net/10045/12846
DOI: 10.1002/ejoc.200900951
ISSN: 1434-193X (Print)
Abstract: 
Nickel nanoparticles were found to promote the Wittig-type olefination of primary alcohols with phosphorus ylides. The latter can be prepared from the corresponding phosphonium salts with nBuLi or in situ generated with lithium metal. The methodology is especially efficient for the synthesis of stilbenes and is applied in the absence of any additive as ahydrogen acceptor. A new approach to the synthesis of polymethoxylated and polyhydroxylated stilbenes, including resveratrol, DMU-212 and analogues, is presented.
Keywords:Alcohols, Olefination, Nickel, Nanoparticles, Wittig reactions
Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
info:eu-repo/semantics/article