Rodríguez Pastor, Iluminada, López-Pérez, Adelia, Romero Sánchez, María Dolores, Pérez, Juana M., Fernández, Ignacio, Martin-Gullon, Ignacio
Effective Method for a Graphene Oxide with Impressive Selectivity in Carboxyl Groups
Rodríguez-Pastor I, López-Pérez A, Romero-Sánchez MD, Pérez JM, Fernández I, Martin-Gullon I. Effective Method for a Graphene Oxide with Impressive Selectivity in Carboxyl Groups. Nanomaterials. 2022; 12(18):3112. https://doi.org/10.3390/nano12183112
URI: http://hdl.handle.net/10045/127974
DOI: 10.3390/nano12183112
ISSN: 2079-4991
Abstract: 
The development of new applications of graphene oxide in the biomedical field requires the covalent bonding of bioactive molecules to a sheet skeleton. Obtaining a large carboxyl group population over the surface is one of the main targets, as carboxyl group concentration in conventional graphene oxide is low among a majority of non-useful sp3-C-based functionalities. In the present work, we propose a selective method that yields an impressive increase in carboxyl group population using single-layer, thermally reduced graphene oxide as a precursor in a conventional Hummers–Offemann reaction. When starting with a reduced graphene oxide with no interlayer registry, sulfuric acid cannot form a graphite intercalated compound. Then, potassium permanganate attacks in in-plane (vacancies or holes) structural defects, which are numerous over a thermally reduced graphene oxide, as well as in edges, yielding majorly carboxyl groups without sheet cutting and unzipping, as no carbon dot formation was observed. A single-layer precursor with no ordered stacking prevents the formation of an intercalated compound, and it is this mechanism of the potassium permanganate that results in carboxyl group formation and the hydrophilic character of the compound.
Keywords:Reduced graphene oxide, Graphite intercalated compound, Carboxyl groups, Bioconjugation
MDPI
info:eu-repo/semantics/article