Andreo-Martínez, Pedro, Rubio-Aparicio, María, Sánchez-Meca, Julio, Veas, Alejandro, Martínez-González, Agustín Ernesto
A Meta-analysis of Gut Microbiota in Children with Autism
Journal of Autism and Developmental Disorders. 2022, 52: 1374-1387. https://doi.org/10.1007/s10803-021-05002-y
URI: http://hdl.handle.net/10045/114724
DOI: 10.1007/s10803-021-05002-y
ISSN: 0162-3257 (Print)
Abstract: 
Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of Streptococcus (SMD+ = − 0.999; 95% CI − 1.549, − 0.449) and Bifidobacterium genera (SMD+ = − 0.513; 95% CI − 0.953, − 0.073) in children with ASD. Overall, the Bifidobacterium genera is involved. However, differences found between studies are attributed to factors such as reporting bias.
Keywords:Autism spectrum disorders (ASD), Gut microbiota, Microbiota-gut-brain axis, Systematic review, Meta-analysis
Springer Nature
info:eu-repo/semantics/article