The association of telomere length with substance use disorders: systematic review and meta-analysis protocol
Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10045/99757
Título: | The association of telomere length with substance use disorders: systematic review and meta-analysis protocol |
---|---|
Autor/es: | Navarro-Mateu, Fernando | Rubio-Aparicio, María | Cayuela, Pedro | Álvarez, Francisco-Javier | Roca-Vega, Agustín | Chirlaque, María Dolores | Cayuela, María Luisa | Husky, Mathilde | Martínez, Salvador | Sánchez-Meca, Julio |
Grupo/s de investigación o GITE: | Psicología Aplicada a la Salud y Comportamiento Humano (PSYBHE) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Psicología de la Salud |
Palabras clave: | Telomere length | Substance use disorders | Meta-analysis | Systematic review |
Área/s de conocimiento: | Personalidad, Evaluación y Tratamiento Psicológico |
Fecha de publicación: | 1-dic-2019 |
Editor: | BMC |
Cita bibliográfica: | Navarro-Mateu, F., Rubio-Aparicio, M., Cayuela, P. et al. The association of telomere length with substance use disorders: systematic review and meta-analysis protocol. Syst Rev 8, 298 (2019) doi:10.1186/s13643-019-1199-x |
Resumen: | Background: The present protocol was designed for a systematic review and meta-analysis aimed at determining the association of telomere length with substance use disorders with the exclusion of nicotine addiction, and to identify potential moderators of the effect of telomere length. Such methodological information may provide guidance to improve the quality of future research on this important topic. Methods: Potential studies will be identified through electronic databases (PubMed/MEDLINE, EMBASE, PsycINFO, and Web of Science) up from inception onwards. The inclusion criteria will include published or unpublished observational studies (cohort, case–control, and cross-sectional studies) reporting telomere length in adult patients with substance use disorder compared with a control group. Non-human studies or other study designs such as reviews, case-only, family-based, and/or population studies with only healthy participants will be excluded, as well as those focused solely on nicotine addiction. The main outcome will be telomere length in adults with substance use disorder (primary) and, specifically, in those with alcohol use disorder (secondary). Two investigators will independently evaluate the preselected studies for possible inclusion and will extract data following a standardized protocol. Disagreements will be resolved by consensus. The risk of bias of all included studies will be assessed using the Newcastle–Ottawa Quality Assessment Scale for non-randomized studies. Data will be converted into standardized mean differences as effect size index, and random-effects models will be used for the meta-analysis. Cochran’s Q statistic, I2 index, and visual inspection of the forest plot will be used to verify study heterogeneity. Subgroup analyses and meta-regressions will be conducted to ascertain heterogeneity. Several sensitivity analyses will be conducted to address the influence of potential confounding factors. Publication bias will be examined using the “funnel plot” method with Duval and Tweedie’s trim-and-fill method and Egger test. Discussion: This systematic review will assess the association of telomere length with substance use disorders aside from nicotine addiction. Systematic review registration: PROSPERO registration number CRD42019119785. |
Patrocinador/es: | The publication of this study is supported by the “Observatorio sobre Drogas de la Región de Murcia” and IMIB-Arrixaca as part of the PEGASUS-Murcia (Psychiatric Enquiry to General Population in Southeast Spain-Murcia) project. |
URI: | http://hdl.handle.net/10045/99757 |
ISSN: | 2046-4053 |
DOI: | 10.1186/s13643-019-1199-x |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1186/s13643-019-1199-x |
Aparece en las colecciones: | INV - PSYBHE - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2019_Navarro-Mateu_etal_SystRev.pdf | 563,23 kB | Adobe PDF | Abrir Vista previa | |
Este ítem está licenciado bajo Licencia Creative Commons