Retinoic acid stimulates HIV-1 transcription in human neuroblastoma SH-SY5Y cells
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Campo DC | Valor | Idioma |
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dc.contributor | Genética Humana y de Mamíferos | en |
dc.contributor.author | Recio, Juan A. | - |
dc.contributor.author | Martínez de la Mata, Jorge | - |
dc.contributor.author | Martín-Nieto, José | - |
dc.contributor.author | Aranda Iriarte, Ana | - |
dc.contributor.other | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | en |
dc.contributor.other | Instituto de Investigaciones Biomédicas | en |
dc.date.accessioned | 2009-02-23T10:28:03Z | - |
dc.date.available | 2009-02-23T10:28:03Z | - |
dc.date.created | 2000-02-01 | - |
dc.date.issued | 2000-03-03 | - |
dc.identifier.citation | RECIO, Juan A., et al. "Retinoic acid stimulates HIV-1 transcription in human neuroblastoma SH-SY5Y cells". FEBS Letters. Vol. 469, Issue 1 (March 2000). ISSN 0014-5793, pp. 118-122 | en |
dc.identifier.issn | 0014-5793 (Print) | - |
dc.identifier.issn | 1873-3468 (Online) | - |
dc.identifier.uri | http://hdl.handle.net/10045/9730 | - |
dc.description.abstract | Although the brain is an important target for the human immunodeficiency virus type 1 (HIV) and viral infection causes neuronal degeneration and dementia, the mechanisms responsible for HIV transcription in neuronal cells are largely unknown. We show here that retinoic acid (RA) stimulates HIV transcription in human neuronal SH-SY5Y cells. The steroid receptor coactivator 1 (SRC-1) enhances the transcriptional response to RA, and the viral protein Tat cooperates with RA and SRC-1 to induce a strong transactivation. These results suggest that retinoid receptors could play an important role as activators of viral gene expression in the human brain. | en |
dc.description.sponsorship | This work was supported by Grant PB97-0135 from the DGES. J.A.R. and J.M.N. have been financed by the Comunidad de Madrid. | en |
dc.language | eng | en |
dc.publisher | Elsevier | en |
dc.publisher | Federation of European Biochemical Societies | en |
dc.subject | Retinoic acid | en |
dc.subject | Neuronal cell | en |
dc.subject | Human immunodeficiency virus type 1 transcription | en |
dc.subject | Tat | en |
dc.subject | Nuclear receptor coactivator | en |
dc.subject.other | Genética | en |
dc.subject.other | Bioquímica y Biología Molecular | en |
dc.title | Retinoic acid stimulates HIV-1 transcription in human neuroblastoma SH-SY5Y cells | en |
dc.type | info:eu-repo/semantics/article | en |
dc.peerreviewed | si | en |
dc.identifier.doi | 10.1016/S0014-5793(00)01249-7 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/S0014-5793(00)01249-7 | - |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | - |
Aparece en las colecciones: | INV - GHM - Artículos de Revistas |
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