Development of a Reference Model for Keratoconus Progression Prediction Based on Characterization of the Course of Nonsurgically Treated Cases
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Título: | Development of a Reference Model for Keratoconus Progression Prediction Based on Characterization of the Course of Nonsurgically Treated Cases |
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Autor/es: | Martínez-Abad, Antonio | Piñero, David P. | Chorro, Elísabet | Bataille, Laurent | Alió, Jorge L. |
Grupo/s de investigación o GITE: | Grupo de Óptica y Percepción Visual (GOPV) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía |
Palabras clave: | Keratoconus | Progression | Corneal aberrations | Keratometry | Corneal topography |
Área/s de conocimiento: | Óptica |
Fecha de publicación: | dic-2018 |
Editor: | Wolters Kluwer Health |
Cita bibliográfica: | Cornea. 2018, 37(12): 1497-1505. doi:10.1097/ICO.0000000000001673 |
Resumen: | Purpose: To evaluate and characterize long-term clinical changes in keratoconus cases not requiring surgical treatment because of the absence of clinically significant visual degradation and to design a predictive model for the progression rate. Methods: This retrospective longitudinal study enrolled 68 nonsurgically treated keratoconic eyes of 46 patients (age range, 18–66 years), with a follow-up period of 6 years ± 12 months. Visual, refractive, topographic, and aberrometric changes were evaluated, detecting the abnormal levels of longitudinal changes in each clinical variable analyzed (percentiles 10% or 90%). Subsequently, the eyes were stratified into progression and no-progression groups based on the different variables evaluated, analyzing baseline differences between them. A progression index (PI%) was defined, and its relationship with baseline data was modeled using multiple linear regression analysis. Results: Significant differences were detected in more quantity of baseline parameters between progression and no-progression groups for changes in sphere, spherical-like and coma-like root mean square, central mean keratometry (KM3mm), corneal asphericity (Q80mm), and central astigmatism (Ast3mm). The progression index (PI%) was defined using these variables, obtaining a mean value of 24.39 ± 51.09% and a median of 1.85%. This parameter was significantly related to the baseline sphere, K23 mm (steepest central keratometry), and Q80 mm (P < 0.001, R2 = 0.429). Conclusions: More pronounced progression seems to be present in myopic eyes with central localized steepening but normal mid-periphery flattening. A new index has been defined to characterize and predict the level of progression in nonsurgically treated keratoconus in a medium–long term. |
Patrocinador/es: | D. P. Piñero has been supported by the Ministry of Economy, Industry and Competitiveness of Spain, within the program Ramón y Cajal, RYC-2016-20471. |
URI: | http://hdl.handle.net/10045/90620 |
ISSN: | 0277-3740 (Print) | 1536-4798 (Online) |
DOI: | 10.1097/ICO.0000000000001673 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2018 Wolters Kluwer Health, Inc. |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1097/ICO.0000000000001673 |
Aparece en las colecciones: | INV - GOPV - Artículos de Revistas |
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Archivo | Descripción | Tamaño | Formato | |
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2018_Martinez-Abad_etal_Cornea_final.pdf | Versión final (acceso restringido) | 327,95 kB | Adobe PDF | Abrir Solicitar una copia |
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