Topical axitinib is a potent inhibitor of corneal neovascularization
Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10045/82753
Título: | Topical axitinib is a potent inhibitor of corneal neovascularization |
---|---|
Autor/es: | Lledó Riquelme, Mariola | Campos Mollo, Ezequiel | Fernández-Sánchez, Laura |
Grupo/s de investigación o GITE: | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía |
Palabras clave: | Axitinib | Tyrosine kinase inhibitor | Corneal neovascularization | Cornea | Angiogenesis |
Área/s de conocimiento: | Farmacología |
Fecha de publicación: | 11-jun-2018 |
Editor: | Wiley |
Cita bibliográfica: | Clinical & Experimental Ophthalmology. 2018, 46(9): 1063-1074. doi:10.1111/ceo.13333 |
Resumen: | Background: This study evaluated the effects of topically applied axitinib, a tyrosine kinase inhibitor, in an experimental model of corneal neovascularization (CNV). Methods: A total of 48 New Zealand rabbits were used. CNV was induced by placing five silk sutures in the upper cornea of one eye per rabbit. Rabbits were randomized into four groups (12 rabbits each): 0.9% saline (control group), 0.02 mg/mL axitinib, 0.35 mg/mL axitinib and 0.5 mg/mL axitinib groups. All treatments were administered three times daily for 14 days. Photographs were taken using a slit lamp on days 7 and 14. The area of neovascularization was measured in mm2, as the percentage of total corneal area and as the percentage of corneal surface covered by sutures (SCS). Results: On day 14, the CNV area in the control group (31.50 ± 7.47 mm2; 115.00 ± 22.55% of the corneal SCS) was larger than that in the 0.02 mg/mL axitinib group (19.20 ± 8.92 mm2; 73.89 ± 34.98%), the 0.35 mg/mL axitinib group (8.83 ± 3.92 mm2; 31.90 ± 13.59%) and the 0.5 mg/mL axitinib group (5.12 ± 3.97 mm2; 18.38 ± 13.65%). Compared with saline, CNV was inhibited 39.04% by 0.02 mg/mL axitinib, 71.96% by 0.35 mg/mL axitinib and 84.73% by 0.5 mg/mL axitinib. Conclusion: Topical administration of the three axitinib concentrations inhibited CNV in rabbits, blocking both vascular endothelial growth factor and platelet‐derived growth factor pathways. Axitinib at 0.5 mg/mL induced profound inhibition of corneal angiogenesis. |
Patrocinador/es: | Publication of this article was supported in part by a research grant from the Institute of Health Carlos III (PS09/02407), Madrid, Spain. |
URI: | http://hdl.handle.net/10045/82753 |
ISSN: | 1442-6404 (Print) | 1442-9071 (Online) |
DOI: | 10.1111/ceo.13333 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © Royal Australian and New Zealand College of Ophthalmologists |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1111/ceo.13333 |
Aparece en las colecciones: | INV - NEUROVIS - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2018_Lledo-Riquelme_etal_C&EO_accepted.pdf | Accepted Manuscript (acceso abierto) | 2,54 MB | Adobe PDF | Abrir Vista previa |
2018_Lledo-Riquelme_etal_C&EO_final.pdf | Versión final (acceso restringido) | 3,56 MB | Adobe PDF | Abrir Solicitar una copia |
Todos los documentos en RUA están protegidos por derechos de autor. Algunos derechos reservados.