First assessment of the comparative toxicity of ivermectin and moxidectin in adult dung beetles: Sub-lethal symptoms and pre-lethal consequences
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http://hdl.handle.net/10045/82108
Títol: | First assessment of the comparative toxicity of ivermectin and moxidectin in adult dung beetles: Sub-lethal symptoms and pre-lethal consequences |
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Autors: | Verdú, José R. | Cortez, Vieyle | Martinez-Pinna, Juan | Ortiz, Antonio J. | Lumaret, Jean-Pierre | Lobo, Jorge M. | Sánchez-Piñero, Francisco | Numa, Catherine |
Grups d'investigació o GITE: | Biodiversidad y Biotecnología aplicadas a la Biología de la Conservación | Fisiología Neuroendocrina (FINE) |
Centre, Departament o Servei: | Universidad de Alicante. Departamento de Ciencias Ambientales y Recursos Naturales | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | Universidad de Alicante. Centro Iberoamericano de la Biodiversidad |
Paraules clau: | Toxicity | Ivermectin | Moxidectin | Adult dung beetles |
Àrees de coneixement: | Zoología | Fisiología |
Data de publicació: | 5-d’octubre-2018 |
Editor: | Springer Nature |
Citació bibliogràfica: | Scientific Reports. 2018, 8: 14885. doi:10.1038/s41598-018-33241-0 |
Resum: | Among macrocyclic lactones (ML), ivermectin (IVM) and moxidectin (MOX) potentially affect all Ecdysozoan species, with dung beetles being particularly sensitive. The comparative effects of IVM and MOX on adult dung beetles were assessed for the first time to determine both the physiological sub-lethal symptoms and pre-lethal consequences. Inhibition of antennal response and ataxia were tested as two intuitive and ecologically relevant parameters by obtaining the lowest observed effect concentration (LOEC) values and interpolating other relevant toxicity thresholds derived from concentration-response curves (IC50, as the concentration of each ML where the antennal response is inhibited by half; and pLC50, as the quantity of ingested ML where partial paralysis was observed by half of treated individuals) from concentration-response curves. Both sub-lethal and pre-lethal symptoms obtained in this study coincided in that IVM was six times more toxic than MOX for adult dung beetles. Values of LOEC, IC50 and pLC50 obtained for IVM and MOX evaluated in an environmental context indicate that MOX, despite needing more time for tis elimination in the faeces, would be twice as harmful to dung beetles as IVM. This approach will be valuable to clarify the real impact of MLs on dung beetle health and to avoid the subsequent environmental consequences. |
Patrocinadors: | Financial support was provided by the project CGL2015-68207-R of the Secretaría de Estado de Investigación–Ministerio de Economía y Competitividad. |
URI: | http://hdl.handle.net/10045/82108 |
ISSN: | 2045-2322 |
DOI: | 10.1038/s41598-018-33241-0 |
Idioma: | eng |
Tipus: | info:eu-repo/semantics/article |
Drets: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
Revisió científica: | si |
Versió de l'editor: | https://doi.org/10.1038/s41598-018-33241-0 |
Apareix a la col·lecció: | INV - FINE - Artículos de Revistas INV - BBaBC - Artículos de Revistas |
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