The discovery of CRISPR in archaea and bacteria
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http://hdl.handle.net/10045/57676
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor | Microbiología Molecular | es_ES |
dc.contributor.author | Mojica, Francisco J.M. | - |
dc.contributor.author | Rodríguez Valera, Francisco | - |
dc.contributor.other | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | es_ES |
dc.contributor.other | Universidad de Alicante. Instituto Multidisciplinar para el Estudio del Medio "Ramón Margalef" | es_ES |
dc.date.accessioned | 2016-09-08T09:09:13Z | - |
dc.date.available | 2016-09-08T09:09:13Z | - |
dc.date.issued | 2016-09 | - |
dc.identifier.citation | The FEBS Journal. 2016, 283(17): 3162-3169. doi:10.1111/febs.13766 | es_ES |
dc.identifier.issn | 1742-464X (Print) | - |
dc.identifier.issn | 1742-4658 (Online) | - |
dc.identifier.uri | http://hdl.handle.net/10045/57676 | - |
dc.description.abstract | CRISPR-Cas are self-/nonself-discriminating systems found in prokaryotic cells. They represent a remarkable example of molecular memory that is hereditarily transmitted. Their discovery can be considered as one of the first fruits of the systematic exploration of prokaryotic genomes. Although this genomic feature was serendipitously discovered in molecular biology studies, it was the availability of multiple complete genomes that shed light about their role as a genetic immune system. Here we tell the story of how this discovery originated and was slowly and painstakingly advanced to the point of understating the biological role of what initially was just an odd genomic feature. | es_ES |
dc.description.sponsorship | FJMM is funded by the Spanish Ministerio de Economía y Competitividad (BIO2014-53029P) and the European Commission/Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (291815 Era-Net ANIHWA). FR-V is funded by projects MEDIMAX BFPU2013-48007-P from the Spanish Ministerio de Economía y Competitividad, MaCuMBA Project 311975 of the European Commission FP7 and PROMETEO II/2014/012 project AQUAMET from the Generalitat Valenciana. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | © 2016 Federation of European Biochemical Societies | es_ES |
dc.subject | Adaptive immunity | es_ES |
dc.subject | Cas | es_ES |
dc.subject | CRISPR | es_ES |
dc.subject | Genomics | es_ES |
dc.subject | Interference | es_ES |
dc.subject | Prokaryote | es_ES |
dc.subject | Repeat | es_ES |
dc.subject.other | Microbiología | es_ES |
dc.title | The discovery of CRISPR in archaea and bacteria | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.peerreviewed | si | es_ES |
dc.identifier.doi | 10.1111/febs.13766 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1111/febs.13766 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/311975 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//BIO2014-53029-P | - |
Aparece en las colecciones: | INV - Microbiología Molecular - Artículos de Revistas Investigaciones financiadas por la UE |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
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2016_Mojica_Rodriguez_TheFEBSJournal_final.pdf | Versión final (acceso restringido) | 262,13 kB | Adobe PDF | Abrir Solicitar una copia |
2016_Mojica_Rodriguez_TheFEBSJournal_accepted.pdf | Accepted Manuscript (acceso abierto) | 238,72 kB | Adobe PDF | Abrir Vista previa |
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