Effects of Bisphenol A on ion channels: Experimental evidence and molecular mechanisms
Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10045/56125
Registro completo de metadatos
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor | Fisiología Neuroendocrina (FINE) | es_ES |
dc.contributor.author | Soriano, Sergi | - |
dc.contributor.author | Ripoll, Cristina | - |
dc.contributor.author | Alonso Magdalena, Paloma | - |
dc.contributor.author | Fuentes, Esther | - |
dc.contributor.author | Quesada, Iván | - |
dc.contributor.author | Nadal, Ángel | - |
dc.contributor.author | Martinez-Pinna, Juan | - |
dc.contributor.other | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | es_ES |
dc.date.accessioned | 2016-06-22T10:11:03Z | - |
dc.date.available | 2016-06-22T10:11:03Z | - |
dc.date.issued | 2016-07 | - |
dc.identifier.citation | Steroids. 2016, 111: 12-20. doi:10.1016/j.steroids.2016.02.020 | es_ES |
dc.identifier.issn | 0039-128X (Print) | - |
dc.identifier.issn | 1878-5867 (Online) | - |
dc.identifier.uri | http://hdl.handle.net/10045/56125 | - |
dc.description.abstract | Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) produced in huge quantities in the manufacture of polycarbonate plastics and epoxy resins. It is present in most humans in developed countries, acting as a xenoestrogen and it is considered an environmental risk factor associated to several diseases. Among the whole array of identified mechanisms by which BPA can interfere with physiological processes in living organisms, changes on ion channel activity is one of the most poorly understood. There is still little evidence about BPA regulation of ion channel expression and function. However, this information is key to understand how BPA disrupts excitable and non-excitable cells, including neurons, endocrine cells and muscle cells. This report is the result of a comprehensive literature review on the effects of BPA on ion channels. We conclude that there is evidence to say that these important molecules may be key end-points for EDCs acting as xenoestrogens. However, more research on channel-mediated BPA effects is needed. Particularly, mechanistic studies to unravel the pathophysiological actions of BPA on ion channels at environmentally relevant doses. | es_ES |
dc.description.sponsorship | The author laboratories are funded by the Ministerio de Economía y Competitividad (SAF2014-58335-P and BFU2013-42789-P) and Generalitat Valenciana (PROMETEOII/2015/016). CIBERDEM is an initiative of the Instituto de Salud Carlos III. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | © 2016 Elsevier Inc. | es_ES |
dc.subject | Bisphenol A | es_ES |
dc.subject | Ion channel | es_ES |
dc.subject | Endocrine disruptor | es_ES |
dc.subject | Environmental doses | es_ES |
dc.subject | 17β-Estradiol | es_ES |
dc.subject | Pancreatic β-cells | es_ES |
dc.subject.other | Fisiología | es_ES |
dc.title | Effects of Bisphenol A on ion channels: Experimental evidence and molecular mechanisms | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.peerreviewed | si | es_ES |
dc.identifier.doi | 10.1016/j.steroids.2016.02.020 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.steroids.2016.02.020 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//SAF2014-58335-P | - |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//BFU2013-42789-P | - |
Aparece en las colecciones: | INV - FINE - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2016_Soriano_etal_Steroids_final.pdf | Versión final (acceso restringido) | 337,89 kB | Adobe PDF | Abrir Solicitar una copia |
2016_Soriano_etal_Steroids_accepted.pdf | Accepted Manuscript (acceso abierto) | 507,62 kB | Adobe PDF | Abrir Vista previa |
Todos los documentos en RUA están protegidos por derechos de autor. Algunos derechos reservados.