Organic distributed feedback laser for label-free biosensing of ErbB2 protein biomarker
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Campo DC | Valor | Idioma |
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dc.contributor | Física de la Materia Condensada | es |
dc.contributor.author | Retolaza, Aritz | - |
dc.contributor.author | Martinez-Perdiguero, Josu | - |
dc.contributor.author | Merino, Santos | - |
dc.contributor.author | Morales-Vidal, Marta | - |
dc.contributor.author | Boj, Pedro G. | - |
dc.contributor.author | Quintana, José A. | - |
dc.contributor.author | Villalvilla, José M. | - |
dc.contributor.author | Díaz-García, María A. | - |
dc.contributor.other | Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía | es |
dc.contributor.other | Universidad de Alicante. Departamento de Física Aplicada | es |
dc.contributor.other | Universidad de Alicante. Instituto Universitario de Materiales | es |
dc.date.accessioned | 2015-10-26T13:10:22Z | - |
dc.date.available | 2015-10-26T13:10:22Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.citation | Sensors and Actuators B: Chemical. 2016, 223: 261-265. doi:10.1016/j.snb.2015.09.093 | es |
dc.identifier.issn | 0925-4005 (Print) | - |
dc.identifier.issn | 1873-3077 (Online) | - |
dc.identifier.uri | http://hdl.handle.net/10045/50561 | - |
dc.description.abstract | The human epidermal growth factor receptor 2 (ErbB2) protein plays an important role in human malignancies. Its overexpression has been recognized as a feature of a malignant cancerous phenotype in breast cancer cell lines, and has become one of the most widely investigated clinical indicators of breast, ovarian, gastrointestinal and lung cancers. In this work a vertically emitting organic distributed feedback (DFB) laser has been used to detect the ErbB2 protein. This DFB laser consists of a polystyrene (PS) film containing a perylenediimide laser dye, deposited over a second-order one dimensional grating fabricated on fused silica by thermal-nanoimprint lithography and subsequent reactive ion etching processes. Specificity of the system to ErbB2 protein biomarker, achieved by functionalizing the PS with anti-ErbB2 monoclonal antibodies, is demonstrated. A concentration limit of detection for ErbB2 protein of 14 ng/mL has been obtained, and no cross-reactivity has been observed with bovine serum albumin (BSA) and tumor necrosis factor alpha (TNFα) proteins. These findings open the possibility of using this type of biosensors in clinical applications. | es |
dc.description.sponsorship | This work was supported by the Spanish Government (MINECO) and the European Community (FEDER) through grant no. MAT-2011–28167-C02. This work was partially funded by the Basque Government within the framework of the Etortek Program (Grant No. IE13-360). M. Morales-Vidal has been partly supported by a MINECO FPI fellowship (no. BES-2009-020747). | es |
dc.language | eng | es |
dc.publisher | Elsevier | es |
dc.rights | © 2015 Elsevier B.V. | es |
dc.subject | Label-free biosensors | es |
dc.subject | Organic lasers | es |
dc.subject | Distributed feedback | es |
dc.subject | Perylenediimides | es |
dc.subject | ErbB2 biomarker | es |
dc.subject.other | Óptica | es |
dc.subject.other | Física Aplicada | es |
dc.subject.other | Física de la Materia Condensada | es |
dc.title | Organic distributed feedback laser for label-free biosensing of ErbB2 protein biomarker | es |
dc.type | info:eu-repo/semantics/article | es |
dc.peerreviewed | si | es |
dc.identifier.doi | 10.1016/j.snb.2015.09.093 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.snb.2015.09.093 | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
Aparece en las colecciones: | INV - Física de la Materia Condensada - Artículos de Revistas INV - GHPO - Artículos de Revistas |
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2016_Retolaza_etal_SensorsB_final.pdf | Versión final (acceso restringido) | 637,21 kB | Adobe PDF | Abrir Solicitar una copia |
2016_Retolaza_etal_SensorsB_accepted.pdf | Accepted Manuscript (acceso abierto) | 161,32 kB | Adobe PDF | Abrir Vista previa |
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