Antidiabetic Actions of an Estrogen Receptor β Selective Agonist
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Título: | Antidiabetic Actions of an Estrogen Receptor β Selective Agonist |
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Autor/es: | Alonso Magdalena, Paloma | Ropero, Ana B. | García Arévalo, Marta | Soriano, Sergi | Quesada, Iván | Muhammed, Sarheed J. | Salehi, Albert | Gustafsson, Jan-Ake | Nadal, Ángel |
Grupo/s de investigación o GITE: | Fisiología de Membranas |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología |
Palabras clave: | Estrogen receptor β | Endocrine pancreas | Diabetes | Glucose | Insuline |
Área/s de conocimiento: | Fisiología |
Fecha de publicación: | jun-2013 |
Editor: | American Diabetes Association |
Cita bibliográfica: | Diabetes. 2013, 62(6): 2015-2025. doi:10.2337/db12-1562 |
Resumen: | The estrogen receptor β (ERβ) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ERβ selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances glucose-stimulated insulin secretion both in mouse and human islets. In vivo experiments showed that a single administration of WAY200070 leads to an increase in plasma insulin levels with a concomitant improved response to a glucose load. Two-week treatment administration increased glucose-induced insulin release and pancreatic β-cell mass and improved glucose and insulin sensitivity. In addition, streptozotocin-nicotinamide–induced diabetic mice treated with WAY200070 exhibited a significant improvement in plasma insulin levels and glucose tolerance as well as a regeneration of pancreatic β-cell mass. Studies performed in db/db mice demonstrated that this compound restored first-phase insulin secretion and enhanced pancreatic β-cell mass. We conclude that ERβ agonists should be considered as new targets for the treatment of diabetes. |
Patrocinador/es: | This work was supported by Generalitat Valenciana grant PROMETEO/2011/080, Ministerio de Economia y Competitividad BFU2011-28358, and Ministerio de Economía y Competitividad BFU2010-21773 and BFU2008-1942; the Swedish Cancer Fund; the Emerging Technology Fund of Texas; and the Robert A. Welch Foundation (E-0004). |
URI: | http://hdl.handle.net/10045/38819 |
ISSN: | 0012-1797 (Print) | 1939-327X (Online) |
DOI: | 10.2337/db12-1562 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details |
Revisión científica: | si |
Versión del editor: | http://dx.doi.org/10.2337/db12-1562 |
Aparece en las colecciones: | INV - Fisiología de Membranas - Artículos de Revistas INV - FINE - Artículos de Revistas |
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