Rapid determination of octanol–water partition coefficient using vortex-assisted liquid–liquid microextraction
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http://hdl.handle.net/10045/37265
Títol: | Rapid determination of octanol–water partition coefficient using vortex-assisted liquid–liquid microextraction |
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Autors: | Román Falco, Iván | Mastromichali, Anna | Tyrovola, Konstantina | Canals, Antonio | Psillakis, Elefteria |
Grups d'investigació o GITE: | Espectroscopía Atómica-Masas y Química Analítica en Condiciones Extremas |
Centre, Departament o Servei: | Universidad de Alicante. Departamento de Química Analítica, Nutrición y Bromatología | Universidad de Alicante. Instituto Universitario de Materiales |
Paraules clau: | Octanol-water partition coefficient | Organic compounds | Liquid-liquid microextraction | Vortex agitation |
Àrees de coneixement: | Química Analítica |
Data de publicació: | 21-de febrer-2014 |
Editor: | Elsevier |
Citació bibliogràfica: | Journal of Chromatography A. 2014, 1330: 1-5. doi:10.1016/j.chroma.2014.01.003 |
Resum: | Vortex-assisted liquid–liquid microextraction (VALLME) coupled with high-performance liquid chromatography (HPLC) is proposed here for the rapid determination of octanol–water partitioning coefficients (Kow). VALLME uses vortex agitation, a mild emulsification procedure, to disperse microvolumes of octanol in the aqueous phase thus increasing the interfacial contact area and ensuring faster partitioning rates. With VALLME, 2 min were enough to achieve equilibrium conditions between the octanolic and aqueous phases. Upon equilibration, separation was achieved using centrifugation and the octanolic microdrop was collected and analyzed in a HPLC system. Six model compounds with log Kow values ranging between ∼0.5 and 3.5 were used during the present investigations. The proposed method produced log Kow values that were consistent with previously published values and the recorded uncertainty was well within the acceptable log unit range. Overall, the key features of the proposed Kow determination procedure comprised speed, reliability, simplicity, low cost and minimal solvent consumption. |
Patrocinadors: | EP is grateful to the Region of Crete (Perifereia Kritis) for funding. Financial support from the Spanish Government (Project CTQ2011-23968) is also acknowledged. I.P.R. also thanks “Caja de Ahorros del Mediterraneo (CAM)” for his predoctoral grant and financial support. |
URI: | http://hdl.handle.net/10045/37265 |
ISSN: | 0021-9673 (Print) | 1873-3778 (Online) |
DOI: | 10.1016/j.chroma.2014.01.003 |
Idioma: | eng |
Tipus: | info:eu-repo/semantics/article |
Revisió científica: | si |
Versió de l'editor: | http://dx.doi.org/10.1016/j.chroma.2014.01.003 |
Apareix a la col·lecció: | INV - SP-BG - Artículos de Revistas |
Arxius per aquest ítem:
Arxiu | Descripció | Tamany | Format | |
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2014_Roman_etal_JournalChromaA_final.pdf | Versión final (acceso restringido) | 584,33 kB | Adobe PDF | Obrir Sol·licitar una còpia |
2014_Roman_etal_JournalChromaA.pdf | Versión revisada (acceso abierto) | 147,34 kB | Adobe PDF | Obrir Vista prèvia |
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