Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β
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Title: | Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β |
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Authors: | Soriano, Sergi | Alonso Magdalena, Paloma | García Arévalo, Marta | Novials, Anna | Muhammed, Sarheed J. | Salehi, Albert | Gustafsson, Jan-Ake | Quesada, Iván | Nadal, Ángel |
Research Group/s: | Fisiología de Membranas |
Center, Department or Service: | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología |
Keywords: | Bisphenol-A | Estrogen receptor β | Islets of Langerhans | Risk factor | Metabolic disorders |
Knowledge Area: | Fisiología |
Issue Date: | 8-Feb-2012 |
Publisher: | Public Library of Science (PLoS) |
Citation: | Soriano S, Alonso-Magdalena P, García-Arévalo M, Novials A, Muhammed SJ, et al. (2012) Rapid Insulinotropic Action of Low Doses of Bisphenol-A on Mouse and Human Islets of Langerhans: Role of Estrogen Receptor β. PLoS ONE 7(2): e31109. doi:10.1371/journal.pone.0031109 |
Abstract: | Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical (EDC) used as the base compound in the manufacture of polycarbonate plastics. It alters pancreatic β-cell function and can be considered a risk factor for type 2 diabetes in rodents. Here we used ERβ−/− mice to study whether ERβ is involved in the rapid regulation of KATP channel activity, calcium signals and insulin release elicited by environmentally relevant doses of BPA (1 nM). We also investigated these effects of BPA in β-cells and whole islets of Langerhans from humans. 1 nM BPA rapidly decreased KATP channel activity, increased glucose-induced [Ca2+]i signals and insulin release in β-cells from WT mice but not in cells from ERβ−/− mice. The rapid reduction in the KATP channel activity and the insulinotropic effect was seen in human cells and islets. BPA actions were stronger in human islets compared to mouse islets when the same BPA concentration was used. Our findings suggest that BPA behaves as a strong estrogen via nuclear ERβ and indicate that results obtained with BPA in mouse β-cells may be extrapolated to humans. This supports that BPA should be considered as a risk factor for metabolic disorders in humans. |
Sponsor: | This research was supported by grants from Ministerio de Ciencia e Innovación grants BFU2008-01492, BFU2011-28358 and BFU2010-21773, Generalitat Valenciana grants Prometeo/2011/080 and ACOMP/2010/113, the European Commission (Program PEOPLE). The “Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas” is an initiative of the Instituto de Salud Carlos III. |
URI: | http://hdl.handle.net/10045/35325 |
ISSN: | 1932-6203 |
DOI: | 10.1371/journal.pone.0031109 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Rights: | © 2012 Soriano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
Peer Review: | si |
Publisher version: | http://dx.doi.org/10.1371/journal.pone.0031109 |
Appears in Collections: | INV - Fisiología de Membranas - Artículos de Revistas INV - FINE - Artículos de Revistas |
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