Organocatalytic enantioselective multicomponent reactions (OEMCRs)
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Title: | Organocatalytic enantioselective multicomponent reactions (OEMCRs) |
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Authors: | Guillena, Gabriela | Ramón, Diego J. | Yus, Miguel |
Research Group/s: | Derivados de Aminoácidos y Péptidos en Síntesis Orgánica |
Center, Department or Service: | Universidad de Alicante. Departamento de Química Orgánica |
Keywords: | Organocatalysis | Multicomponent | Eenantioselective | Asymmetric synthesis | Amino acids | Proline |
Knowledge Area: | Química Orgánica |
Date Created: | 2007 |
Issue Date: | 16-Apr-2007 |
Publisher: | Elsevier |
Citation: | GUILLENA TOWNLEY, Gabriela; RAMÓN DANGLA, Diego José; YUS ASTIZ, Miguel. "Organocatalytic enantioselective multicomponent reactions (OEMCRs)". Tetrahedron: Asymmetry. Vol. 18, Issue 6 (16 Apr. 2007). ISSN 0957-4166, pp. 693-700 |
Abstract: | The achieved level of expertise in organocatalytic processes has allowed synthetic chemists to apply this useful synthetic strategy to enantioselective multicomponent reactions. Although, this new methodology is still in its infancy, the reported results show the possibilities and versatility of this type of reaction, with an extraordinary level of atom efficiency being reached. All examples, from classical Mannich, Biginelli, Michael, and Diels–Alder reactions to new amination–reduction and Tietze reactions, allow the synthesis of complex chiral molecules with several stereogenic elements created in just one process. In fact, the organocatalyst acts in this type of process as a clear enzyme mimic, but with an ample substrate scope. |
Sponsor: | We are grateful to the Spanish Ministerio de Educación y Ciencia, as well as to Generalitat Valenciana, for their continuous financial support. |
URI: | http://hdl.handle.net/10045/2576 |
ISSN: | 0957-4166 |
DOI: | 10.1016/j.tetasy.2007.03.002 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Peer Review: | si |
Publisher version: | http://dx.doi.org/10.1016/j.tetasy.2007.03.002 |
Appears in Collections: | INV - DAPSO - Artículos INV - MESO - Artículos de Revistas INV - SINTAS - Artículos de Revistas INV - MATCAT - Artículos de Revistas INV - CESO - Artículos de Revistas INV - AMIC - Artículos de Revistas |
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