Three-component coupling of aldehydes, amines and alkynes catalyzed by oxidized copper nanoparticles on titania
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Campo DC | Valor | Idioma |
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dc.contributor | Nuevas Metodologías en Síntesis Orgánica | es |
dc.contributor.author | Albaladejo Maricó, María José | - |
dc.contributor.author | Alonso, Francisco | - |
dc.contributor.author | Moglie, Yanina | - |
dc.contributor.author | Yus, Miguel | - |
dc.contributor.other | Universidad de Alicante. Departamento de Química Orgánica | es |
dc.date.accessioned | 2012-05-28T10:53:01Z | - |
dc.date.available | 2012-05-28T10:53:01Z | - |
dc.date.created | 2012 | - |
dc.date.issued | 2012-03-15 | - |
dc.identifier.citation | ALBALADEJO, María José, et al. "Three-component coupling of aldehydes, amines and alkynes catalyzed by oxidized copper nanoparticles on titania". European Journal of Organic Chemistry. Vol. 2012, Issue 16 (June 2012). ISSN 1434-193X, pp. 3093-3104 | es |
dc.identifier.issn | 1434-193X (Print) | - |
dc.identifier.issn | 1099-0690 (Online) | - |
dc.identifier.uri | http://hdl.handle.net/10045/22590 | - |
dc.description.abstract | Copper nanoparticles (mainly as Cu2O) on titania have been shown to catalyze the multicomponent synthesis of propargylamines from aldehydes, amines, and alkynes (A3 coupling) effectively at 70 °C under solvent-free conditions. Both aromatic and aliphatic aldehydes and alkynes have been combined with secondary amines to provide a wide range of propargylamines in moderate to excellent yields. Two examples of ketone/amine/alkyne (KA2) coupling are also included. The catalyst is easy to prepare, reusable at a low copper loading (0.5 mol-%), and exhibits higher catalytic activity than some commercially available copper sources. Some mechanistic aspects of the reaction have also been examined, which have unveiled the participation of copper(I) acetylides in a heterogeneous process. | es |
dc.description.sponsorship | This work was generously supported by the Spanish Ministerio de Ciencia e Innovación (MICINN) (grant numbers CTQ2007-65218, CTQ2011-24151), Consolider Ingenio (grant number 2010-CSD2007-00006), the Generalitat Valenciana (grant number PROMETEO/2009/039), and Fondos Europeos para el Desarrollo Regional (FEDER). Y. M. and M. J .A. acknowledge the ISO of the Universidad de Alicante for a grant. | es |
dc.language | eng | es |
dc.publisher | Wiley-VCH Verlag GmbH & Co. KGaA | es |
dc.rights | The definitive version is available at www3.interscience.wiley.com | es |
dc.subject | Multicomponent reactions | es |
dc.subject | Nanoparticles | es |
dc.subject | Copper | es |
dc.subject | Alkynes | es |
dc.subject | Aldehydes | es |
dc.subject | Amines | es |
dc.subject.other | Química Orgánica | es |
dc.title | Three-component coupling of aldehydes, amines and alkynes catalyzed by oxidized copper nanoparticles on titania | es |
dc.type | info:eu-repo/semantics/article | es |
dc.peerreviewed | si | es |
dc.identifier.doi | 10.1002/ejoc.201200090 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1002/ejoc.201200090 | es |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | es |
Aparece en las colecciones: | INV - MESO - Artículos de Revistas INV - MATCAT - Artículos de Revistas INV - SINTAS - Artículos de Revistas |
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