Interaction of sedentary behaviour and educational level in breast cancer risk
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Título: | Interaction of sedentary behaviour and educational level in breast cancer risk |
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Autor/es: | Pinto-Carbó, Marina | Vanaclocha-Espi, Mercedes | Ibáñez, Josefa | Martín-Pozuelo, Javier | Romeo-Cervera, Paula | Nolasco, Andreu | Besó-Delgado, María | Castán, Susana | Salas, Dolores | Molina-Barceló, Ana |
Grupo/s de investigación o GITE: | Salud Comunitaria (SALUD) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia |
Palabras clave: | Sedentary behaviour | Educational level | Breast cancer risk |
Fecha de publicación: | 16-may-2024 |
Editor: | Public Library of Science (PLoS) |
Cita bibliográfica: | PLoS ONE. 2024, 19(5): e0300349. https://doi.org/10.1371/journal.pone.0300349 |
Resumen: | Objective This cross-sectional study aims to analyse the relationship between sedentary behaviour and breast cancer (BC) risk from a social perspective. Methods Women aged 45–70 who participated in the Valencia Region Breast Cancer Screening Programme (2018–2019) were included, with a total of 121,359 women analysed, including 506 with cancer and 120,853 without cancer. The response variable was BC (screen-detected) and the main explanatory variable was sedentary behaviour (≤2 / >2-≤3 / >3-≤5 / >5 hours/day, h/d). Nested logistic regression models (M) were estimated: M1: sedentary behaviour adjusted for age and family history of BC; M2: M1 + hormonal/reproductive variables (menopausal status, number of pregnancies, hormone replacement therapy; in addition, months of breastfeeding was added for a subsample of women with one or more live births); M3: M2 + lifestyle variables (body mass index, smoking habits); M4: M3 + socioeconomic variables (educational level, occupation); Final model: M4 + gender variables (childcare responsibilities, family size). Interaction between sedentary behaviour and educational level was analysed in the Final model. Moreover, for the whole sample, postmenopausal women and HR+ BC, the Final model was stratified by educational level. Results Sedentary behaviour was associated with an increased risk of BC with a nearly statistically significant effect in the Final model (>2-≤3 h/d: OR = 1.22 (0.93–1.61); >3-≤5 h/d: OR = 1.14 (0.86–1.52); >5: OR = 1.19 (0.89–1.60)). For women with a low educational level, sitting more than 2 h/d was associated with an increased risk of BC in the whole sample (>2-≤3 h/d OR = 1.93 (1.19–3.21); in postmenopausal women (>2-≤3 h/d, OR = 2.12 (1.18–2.96), >5h/d OR = 1.75 (1.01–3.11)) and in HR+ BC (>2-≤3h/d, OR = 2.15 (1.22–3.99)). Similar results were observed for women with one or more live births. Conclusions Sitting >2 h/d is associated with BC risk in women with low educational level, especially in postmenopausal women and those with live births. |
Patrocinador/es: | M.P-C: This work was supported by the Generalitat Valenciana and the European Social Fund [grant number ACIF/2019/085]. |
URI: | http://hdl.handle.net/10045/143020 |
ISSN: | 1932-6203 |
DOI: | 10.1371/journal.pone.0300349 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2024 Pinto-Carbó et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1371/journal.pone.0300349 |
Aparece en las colecciones: | INV - SALUD - Artículos de Revistas |
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