Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study
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Título: | Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study |
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Autor/es: | Navarrete-Muñoz, Eva María | Valera-Gran, Desirée | García de la Hera, Manuela | Gimenez-Monzo, Daniel | Morales, Eva | Julvez, Jordi | Riaño, Isolina | Tardón, Adonina | Ibarluzea, Jesus | Santa Marina, Loreto | Murcia, Mario | Rebagliato, Marisa | Vioque López, Jesús |
Grupo/s de investigación o GITE: | Grupo de Investigación en Alimentación y Nutrición (ALINUT) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia |
Palabras clave: | Folic acid supplements | Pregnant women | Spain | Cohort study |
Fecha de publicación: | 24-nov-2015 |
Editor: | BMJ |
Cita bibliográfica: | BMJ Open. 2015, 5: e009202. https://doi.org/10.1136/bmjopen-2015-009202 |
Resumen: | Objectives We examined the use of low (<400 μg/day, including no use) and high folic acid supplement (FAS) dosages (≥1000 μg/day) among pregnant women in Spain, and explored factors associated with the use of these non-recommended dosages. Design Population-based cohort study. Setting Spain. Participants We analysed data from 2332 pregnant women of the INMA study, a prospective mother-child cohort study in Spain. Main outcome measures We assessed usual dietary folate and the use of FAS from preconception to the 3rd month (first period) and from the 4th to the 7th month (second period), using a validated food frequency questionnaire. We used multinomial logistic regression to estimate relative risk ratios (RRRs). Results Over a half of the women used low dosages of FAS in the first and second period while 29% and 17% took high dosages of FAS, respectively. In the first period, tobacco smoking (RRR=1.63), alcohol intake (RRR=1.40), multiparous (RRR=1.44), unplanned pregnancy (RRR=4.20) and previous spontaneous abortion (RRR=0.58, lower use of high FAS dosages among those with previous abortions) were significantly associated with low FAS dosages. Alcohol consumption (RRR=1.42), unplanned pregnancy (RRR=2.66) and previous spontaneous abortion (RRR=0.68) were associated with high dosage use. In the second period, only tobacco smoking was significantly associated with high FAS dosage use (RRR=0.67). Conclusions A high proportion of pregnant women did not reach the recommended dosages of FAS in periconception and a considerable proportion also used FAS dosages ≥1000 μg/day. Action should be planned by the Health Care System and health professionals to improve the appropriate periconceptional use of FAS, taking into consideration the associated factors. |
Patrocinador/es: | This study was funded by grants from Instituto de Salud Carlos III and Spanish Ministry of Health (Red INMA G03/176; CB06/02/0041; FIS 97/0588; 00/0021–2, PI061756; PS0901958; FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314; 09/02647; FIS-PI041436, FIS-PI081151, FIS-PI06/0867; FIS-PS09/00090, FIS-PI042018, FIS-PI09 02311, FIS PI11/01007, FISPI13/02429) Universidad de Oviedo, Conselleria de Sanitat Generalitat Valenciana, Generalitat de Catalunya-CIRIT 1999SGR 00241, Department of Health of the Basque Government (2005111093 and 2009111069) and the Provincial Government of Guipuzcoa (DFG06/004 and DFG08/001). |
URI: | http://hdl.handle.net/10045/140543 |
ISSN: | 2044-6055 |
DOI: | 10.1136/bmjopen-2015-009202 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1136/bmjopen-2015-009202 |
Aparece en las colecciones: | INV - ALINUT - Artículos de Revistas |
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