Non-haematopoietic Sca-1+ Cells in the Retina of Adult Mice Express Functional TLR2
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http://hdl.handle.net/10045/139769
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DC Field | Value | Language |
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dc.contributor | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) | es_ES |
dc.contributor.author | Flores, Ana | - |
dc.contributor.author | Fernández-Sánchez, Laura | - |
dc.contributor.author | Kutsyr, Oksana | - |
dc.contributor.author | Lax, Pedro | - |
dc.contributor.author | Yáñez, Alberto | - |
dc.contributor.author | Gil, María Luisa | - |
dc.contributor.author | Gozalbo, Daniel | - |
dc.contributor.author | Maneu, Victoria | - |
dc.contributor.other | Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía | es_ES |
dc.contributor.other | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | es_ES |
dc.date.accessioned | 2024-01-16T11:16:27Z | - |
dc.date.available | 2024-01-16T11:16:27Z | - |
dc.date.issued | 2024-01-06 | - |
dc.identifier.citation | Stem Cell Reviews and Reports. 2024. https://doi.org/10.1007/s12015-023-10674-3 | es_ES |
dc.identifier.issn | 2629-3269 (Print) | - |
dc.identifier.issn | 2629-3277 (Online) | - |
dc.identifier.uri | http://hdl.handle.net/10045/139769 | - |
dc.description.abstract | The mammal retina does not have the capacity to regenerate throughout life, although some stem and progenitor cells persist in the adult retina and might retain multipotentiality, as previously described in many tissues. In this work we demonstrate the presence of a small lineage− Sca-1+ cell population in the adult mouse retina which expresses functional TLR2 receptors as in vitro challenge with the pure TLR2 agonist Pam3CSK4 increases cell number and upregulates TLR2. Therefore, this population could be of interest in neuroregeneration studies to elucidate its role in these processes. | es_ES |
dc.description.sponsorship | Generalitat Valenciana (PROMETEO/2021/024). | es_ES |
dc.language | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.rights | © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024 | es_ES |
dc.subject | Retina | es_ES |
dc.subject | Stem cells | es_ES |
dc.subject | VSELs | es_ES |
dc.subject | TLR2 | es_ES |
dc.subject | Regeneration | es_ES |
dc.title | Non-haematopoietic Sca-1+ Cells in the Retina of Adult Mice Express Functional TLR2 | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.peerreviewed | si | es_ES |
dc.identifier.doi | 10.1007/s12015-023-10674-3 | - |
dc.relation.publisherversion | https://doi.org/10.1007/s12015-023-10674-3 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | es_ES |
Appears in Collections: | INV - NEUROVIS - Artículos de Revistas |
Files in This Item:
File | Description | Size | Format | |
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Flores_etal_2024_StemCellRevRep_final.pdf | Versión final (acceso restringido) | 2,53 MB | Adobe PDF | Open Request a copy |
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