Automated Axial Right Ventricle to Left Ventricle Diameter Ratio Computation in Computed Tomography Pulmonary Angiography
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http://hdl.handle.net/10045/138544
Títol: | Automated Axial Right Ventricle to Left Ventricle Diameter Ratio Computation in Computed Tomography Pulmonary Angiography |
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Autors: | González, Germán | Jiménez-Carretero, Daniel | Rodríguez-López, Sara | Kumamaru, Kanako K. | George, Elizabeth | San José Estépar, Raúl | Rybicki, Frank J. | Ledesma-Carbayo, Maria J. |
Grups d'investigació o GITE: | Robótica y Visión Tridimensional (RoViT) |
Centre, Departament o Servei: | Universidad de Alicante. Departamento de Ciencia de la Computación e Inteligencia Artificial |
Paraules clau: | Computed Tomography Pulmonary Angiography | Right Ventricular to Left Ventricular | Diameter Ratio Computation | Pulmonary Embolism |
Data de publicació: | 22-de maig-2015 |
Editor: | Public Library of Science (PLoS) |
Citació bibliogràfica: | PLoS ONE. 2015, 10(5): e0127797. https://doi.org/10.1371/journal.pone.0127797 |
Resum: | Background and Purpose Right Ventricular to Left Ventricular (RV/LV) diameter ratio has been shown to be a prognostic biomarker for patients suffering from acute Pulmonary Embolism (PE). While Computed Tomography Pulmonary Angiography (CTPA) images used to confirm a clinical suspicion of PE do include information of the heart, a numerical RV/LV diameter ratio is not universally reported, likely because of lack in training, inter-reader variability in the measurements, and additional effort by the radiologist. This study designs and validates a completely automated Computer Aided Detection (CAD) system to compute the axial RV/LV diameter ratio from CTPA images so that the RV/LV diameter ratio can be a more objective metric that is consistently reported in patients for whom CTPA diagnoses PE. Materials and Methods The CAD system was designed specifically for RV/LV measurements. The system was tested in 198 consecutive CTPA patients with acute PE. Its accuracy was evaluated using reference standard RV/LV radiologist measurements and its prognostic value was established for 30-day PE-specific mortality and a composite outcome of 30-day PE-specific mortality or the need for intensive therapies. The study was Institutional Review Board (IRB) approved and HIPAA compliant. Results The CAD system analyzed correctly 92.4% (183/198) of CTPA studies. The mean difference between automated and manually computed axial RV/LV ratios was 0.03±0.22. The correlation between the RV/LV diameter ratio obtained by the CAD system and that obtained by the radiologist was high (r=0.81). Compared to the radiologist, the CAD system equally achieved high accuracy for the composite outcome, with areas under the receiver operating characteristic curves of 0.75 vs. 0.78. Similar results were found for 30-days PE-specific mortality, with areas under the curve of 0.72 vs. 0.75. Conclusions An automated CAD system for determining the CT derived RV/LV diameter ratio in patients with acute PE has high accuracy when compared to manual measurements and similar prognostic significance for two clinical outcomes. |
Patrocinadors: | This project has been financially supported by the Comunidad de Madrid, Spain through the Madrid-MIT M+Vision Consortium. Daniel Jimenez was supported by an FPU grant by the Spain' s Ministry of Education. |
URI: | http://hdl.handle.net/10045/138544 |
ISSN: | 1932-6203 |
DOI: | 10.1371/journal.pone.0127797 |
Idioma: | eng |
Tipus: | info:eu-repo/semantics/article |
Drets: | © 2015 González et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
Revisió científica: | si |
Versió de l'editor: | https://doi.org/10.1371/journal.pone.0127797 |
Apareix a la col·lecció: | INV - RoViT - Artículos de Revistas |
Arxius per aquest ítem:
Arxiu | Descripció | Tamany | Format | |
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Gonzalez_etal_2015_PLoS-ONE.pdf | 2,4 MB | Adobe PDF | Obrir Vista prèvia | |
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