Recent insights about pyrrolidine core skeletons in pharmacology
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Título: | Recent insights about pyrrolidine core skeletons in pharmacology |
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Autor/es: | Poyraz, Samet | Dondas, H. Ali | Döndaş, Naciye Yaktubay | Sansano, Jose M. |
Grupo/s de investigación o GITE: | Síntesis Asimétrica (SINTAS) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
Palabras clave: | Pyrrolidine | Pyrrolidine 2,5-dione | Natural products | Cytotoxicity | Pharmaceuticals |
Fecha de publicación: | 6-sep-2023 |
Editor: | Frontiers Media |
Cita bibliográfica: | Poyraz S, Döndaş HA, Döndaş NY and Sansano JM (2023) Recent insights about pyrrolidine core skeletons in pharmacology. Front. Pharmacol. 14:1239658. doi: 10.3389/fphar.2023.1239658 |
Resumen: | To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin are utilized, and notably, the emergence of various side effects of existing drugs used for treatment or the resistance of disease-causing microorganisms renders drugs ineffective. Therefore, the discovery of potential therapeutic agents that utilize different modes of action is of utmost significance to circumvent these constraints. Pyrrolidines, pyrrolidine-alkaloids, and pyrrolidine-based hybrid molecules are present in many natural products and pharmacologically important agents. Their key roles in pharmacotherapy make them a versatile scaffold for designing and developing novel biologically active compounds and drug candidates. This review aims to provide an overview of recent advancements (especially during 2015–2023) in the exploration of pyrrolidine derivatives, emphasizing their significance as fundamental components of the skeletal structure. In contrast to previous reviews that have predominantly focused on a singular biological activity associated with these molecules, this review consolidates findings from various investigations encompassing a wide range of important activities (antimicrobial, antiviral, anticancer, anti-inflammatory, anticonvulsant, cholinesterase inhibition, and carbonic anhydrase inhibition) exhibited by pyrrolidine derivatives. This study is also anticipated to serve as a valuable resource for drug research and development endeavors, offering significant insights and guidance. |
Patrocinador/es: | We gratefully acknowledge financial support from Çukurova University (Project Nos: TSA-2022-15050, TSA-2021-13814 and FYL-2023-15939). The authors also thank the Spanish Ministerio de Ciencia, Innovación y Universidades (project RED 2018-102387-T), the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ 2017-82935-P and PID 2019-107268 GB-I00), the Generalitat Valenciana (IDIFEDER/2021/013 and GVA-COVID19/2021/079), Medalchemy S. L. (Medalchemy-18T), and the University of Alicante (VIGROB-068 and UAUSTI21-05). |
URI: | http://hdl.handle.net/10045/136983 |
ISSN: | 1663-9812 |
DOI: | 10.3389/fphar.2023.1239658 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2023 Poyraz, Döndaş, Döndaş and Sansano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.3389/fphar.2023.1239658 |
Aparece en las colecciones: | INV - SINTAS - Artículos de Revistas |
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