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Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy

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dc.contributorNeurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)es_ES
dc.contributor.authorMartínez Gil, Natalia-
dc.contributor.authorKutsyr, Oksana-
dc.contributor.authorNoailles, Agustina-
dc.contributor.authorFernández-Sánchez, Laura-
dc.contributor.authorVidal, Lorena-
dc.contributor.authorSánchez-Sáez, Xavier-
dc.contributor.authorSánchez-Castillo, Carla-
dc.contributor.authorLax, Pedro-
dc.contributor.authorCuenca, Nicolás-
dc.contributor.authorGarcía, Antonio G.-
dc.contributor.authorManeu, Victoria-
dc.contributor.otherUniversidad de Alicante. Departamento de Fisiología, Genética y Microbiologíaes_ES
dc.contributor.otherUniversidad de Alicante. Departamento de Óptica, Farmacología y Anatomíaes_ES
dc.date.accessioned2023-01-09T12:32:34Z-
dc.date.available2023-01-09T12:32:34Z-
dc.date.issued2022-11-25-
dc.identifier.citationMartínez-Gil N, Kutsyr O, Noailles A, Fernández-Sánchez L, Vidal L, Sánchez-Sáez X, Sánchez-Castillo C, Lax P, Cuenca N, García AG, Maneu V. Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy. International Journal of Molecular Sciences. 2022; 23(23):14758. https://doi.org/10.3390/ijms232314758es_ES
dc.identifier.issn1422-0067-
dc.identifier.urihttp://hdl.handle.net/10045/130881-
dc.description.abstractThe purinergic receptor P2X7 (P2X7R) is implicated in all neurodegenerative diseases of the central nervous system. It is also involved in the retinal degeneration associated with glaucoma, age-related macular degeneration, and diabetic retinopathy, and its overexpression in the retina is evident in these disorders. Retinitis pigmentosa is a progressive degenerative disease that ultimately leads to blindness. Here, we investigated the expression of P2X7R during disease progression in the rd10 mouse model of RP. As the purinergic receptor P2X4 is widely co-expressed with P2X7R, we also studied its expression in the retina of rd10 mice. The expression of P2X7R and P2X4R was examined by immunohistochemistry, flow cytometry, and western blotting. In addition, we analyzed retinal functionality by electroretinographic recordings of visual responses and optomotor tests and retinal morphology. We found that the expression of P2X7R and P2X4R increased in rd10 mice concomitant with disease progression, but with different cellular localization. Our findings suggest that P2X7R and P2X4R might play an important role in RP progression, which should be further analyzed for the pharmacological treatment of inherited retinal dystrophies.es_ES
dc.description.sponsorshipThis research was funded by grants from the Spanish Ministry of the Economy and Competitiveness (RTI2018-094248-B-I00), Spanish Ministry of Science and Innovation co-financed by European Regional Development Fund (MICINN-FEDER PID2019-106230RB-I00), Instituto de Salud Carlos III co-financed by European Regional Development Fund (RETICS-FEDER-RD16/0008/0016), Asociación Retina Asturias (ASOCIACIONRETINA1-20I), and Generalitat Valenciana (PROMETEO/2021/024, IDIFEDER/2017/064), and by a grant (MARSALAS21-35) to L.V.es_ES
dc.languageenges_ES
dc.publisherMDPIes_ES
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).es_ES
dc.subjectRetinitis pigmentosaes_ES
dc.subjectPurinergic receptorses_ES
dc.subjectRetinaes_ES
dc.subjectDegenerationes_ES
dc.subjectInflammationes_ES
dc.subjectP2X7 receptores_ES
dc.subjectP2X4 receptores_ES
dc.titlePurinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.peerreviewedsies_ES
dc.identifier.doi10.3390/ijms232314758-
dc.relation.publisherversionhttps://doi.org/10.3390/ijms232314758es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094248-B-I00es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106230RB-I00es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII//RD16%20008%20016es_ES
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