N-Benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an imidazole moiety: Synthesis, characterization, crystal structure, in vitro ChEs inhibition, and antituberculosis, antibacterial, antifungal studies
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Título: | N-Benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an imidazole moiety: Synthesis, characterization, crystal structure, in vitro ChEs inhibition, and antituberculosis, antibacterial, antifungal studies |
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Autor/es: | Poyraz, Samet | Dondas, H. Ali | Sansano, Jose M. | Belveren, Samet | Yamali, Cem | Ülger, Mahmut | Döndaş, Naciye Yaktubay | Sağlık, Begüm Nurpelin | Pask, Christopher M. |
Grupo/s de investigación o GITE: | Síntesis Asimétrica (SINTAS) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
Palabras clave: | Alzheimer | Antituberculosis | Antibacterial | Antifungal | Heterocycles |
Fecha de publicación: | 14-oct-2022 |
Editor: | Elsevier |
Cita bibliográfica: | Journal of Molecular Structure. 2023, 1273: 134303. https://doi.org/10.1016/j.molstruc.2022.134303 |
Resumen: | A series of novel N-benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an imidazole moiety has been prepared and their various biological activities are evaluated. The ability of forming intermolecular hydrogen-bonds of these molecules was pursued in the search of the best antimicrobial activity. The synthesized compounds were tested to search whether they had an enzyme inhibitory potency against AChE and BChE, which are the main targets for Alzheimer's disease. The prepared compounds were also screened for antituberculosis activity against M. tuberculosis H37Rv strain and the antibacterial activity against E. coli, A. baumannii, S. aureus, B. subtilis, A. hydrophila, bacteria. In addition, their antifungal activities are also evaluated against C. tropicalis, C. albicans, C. glabrata strains. |
Patrocinador/es: | This work is a part of Samet POYRAZ's Ph.D. thesis granted by Mersin University (Project no: 2019-1-TP3-3463) and (Project no: 2020-1 AP4-3982). We also gratefully acknowledge support from Çukurova University (Project no: TSA-2021-13814), Alicante University and Mersin University. |
URI: | http://hdl.handle.net/10045/129047 |
ISSN: | 0022-2860 (Print) | 1872-8014 (Online) |
DOI: | 10.1016/j.molstruc.2022.134303 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2022 Elsevier B.V. |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1016/j.molstruc.2022.134303 |
Aparece en las colecciones: | INV - SINTAS - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
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Poyraz_etal_2023_JMolStruct_final.pdf | Versión final (acceso restringido) | 1,46 MB | Adobe PDF | Abrir Solicitar una copia |
Poyraz_etal_2023_JMolStruct_accepted.pdf | Embargo 24 meses (acceso abierto: 15 oct. 2024) | 1,28 MB | Adobe PDF | Abrir Solicitar una copia |
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