Detection of Neutralizing Antibodies against SARS-CoV-2 Post-Vaccination in Health Care Workers of a Large Tertiary Hospital in Spain by Using a Rapid Test LFIC and sVNT-ELISA
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor | Salud Comunitaria (SALUD) | es_ES |
dc.contributor | Enfermería y Cultura de los Cuidados (EYCC) | es_ES |
dc.contributor | Grupo de Investigación en Alimentación y Nutrición (ALINUT) | es_ES |
dc.contributor | Psicología Aplicada a la Salud y Comportamiento Humano (PSYBHE) | es_ES |
dc.contributor.author | Tuells, José | - |
dc.contributor.author | Parra Grande, Mónica | - |
dc.contributor.author | Santos-Calle, Francisco J. | - |
dc.contributor.author | Montagud, Ana C. | - |
dc.contributor.author | Egoavil, Cecilia | - |
dc.contributor.author | García-Rivera, Celia | - |
dc.contributor.author | Caballero, Pablo | - |
dc.contributor.author | Gabaldón Bravo, Eva María | - |
dc.contributor.author | Rodríguez-Díaz, Juan Carlos | - |
dc.contributor.author | Hurtado-Sánchez, José Antonio | - |
dc.contributor.other | Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia | es_ES |
dc.contributor.other | Universidad de Alicante. Departamento de Enfermería | es_ES |
dc.date.accessioned | 2022-03-28T07:51:42Z | - |
dc.date.available | 2022-03-28T07:51:42Z | - |
dc.date.issued | 2022-03-25 | - |
dc.identifier.citation | Tuells J, Parra-Grande M, Santos-Calle FJ, Montagud AC, Egoavil CM, García-Rivera C, Caballero P, Gabaldón-Bravo EM, Rodríguez-Diaz JC, Hurtado-Sánchez JA. Detection of Neutralizing Antibodies against SARS-CoV-2 Post-Vaccination in Health Care Workers of a Large Tertiary Hospital in Spain by Using a Rapid Test LFIC and sVNT-ELISA. Vaccines. 2022; 10(4):510. https://doi.org/10.3390/vaccines10040510 | es_ES |
dc.identifier.issn | 2076-393X | - |
dc.identifier.uri | http://hdl.handle.net/10045/122408 | - |
dc.description.abstract | The presence of neutralizing antibodies (NAbs) against SARS-CoV-2 represent a surrogate marker of immunologic protection in populations at high risk of infection such as healthcare workers caring for hospitalized patients with COVID-19. As recommended by CDC and the European CDC, the use of rapid diagnostic tests during population-based evaluations offers an opportunity to identify individuals with serologic evidence of natural infection or who have undergone vaccination. We carried out a cross-sectional study to assess the presence of neutralizing antibodies against SARS-CoV-2 among medical providers at an intensive care unit of a large referral hospital in Alicante, Spain. In addition, we tested for the presence of neutralizing antibodies compared to serum of uninfected individuals from a Biobank. We were also interested in evaluating the use of a rapid lateral flow immunochromatography (LFIC) test against a surrogate ELISA viral neutralization test (sVNT). This rapid test demonstrated a specificity of 1.000 95% CI (0.91–1.00) and the sensitivity of 0.987 95% CI (0.93–1.00). The negative predictive value was 95%. After six months, this rapid test demonstrated that those immunized with two doses of BioNTech/Pfizer vaccine, maintained optimal levels of neutralizing antibodies. We concluded that all Health Care Workers develop NAbs and the use of this rapid immunochromatographic test represents a potential tool to be used in population-based studies to detect serological antibody responses to vaccination. Vaccination policies could benefit from this tool to assess additional doses of vaccine or boosters among high-risk populations. | es_ES |
dc.description.sponsorship | This work was supported by an advisory contract from the University of Alicante with reference WENZHOU-OJABIO1-21T and no one reports personal fees received from the biotech company. | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.subject | Neutralizing antibodies | es_ES |
dc.subject | COVID-19 | es_ES |
dc.subject | SARS-CoV-2 | es_ES |
dc.subject | Serological test | es_ES |
dc.subject | Immunoassay | es_ES |
dc.subject | Lateral flow assay | es_ES |
dc.subject | Lateral flow immunochromatography | es_ES |
dc.subject | Sensitivity and specificity | es_ES |
dc.subject.other | Enfermería | es_ES |
dc.title | Detection of Neutralizing Antibodies against SARS-CoV-2 Post-Vaccination in Health Care Workers of a Large Tertiary Hospital in Spain by Using a Rapid Test LFIC and sVNT-ELISA | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.peerreviewed | si | es_ES |
dc.identifier.doi | 10.3390/vaccines10040510 | - |
dc.relation.publisherversion | https://doi.org/10.3390/vaccines10040510 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
Aparece en las colecciones: | INV - SALUD - Artículos de Revistas Cátedra Balmis de Vacunología - Publicaciones INV - PSYBHE - Artículos de Revistas INV - EYCC - Artículos de Revistas INV - ALINUT - Artículos de Revistas |
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