Associations of paternal serum dioxin-like polychlorinated biphenyl concentrations on IVF success: A pilot study
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Título: | Associations of paternal serum dioxin-like polychlorinated biphenyl concentrations on IVF success: A pilot study |
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Autor/es: | Paul, Raiza | Romero, Alejandro | Moltó Berenguer, Julia | Ortuño García, Nuria | Aizpurua, Jon | Gómez-Torres, María José |
Grupo/s de investigación o GITE: | Grupo de Inmunología, Biología Celular y del Desarrollo | Ingeniería para la Economía Circular (I4CE) | Residuos, Energía, Medio Ambiente y Nanotecnología (REMAN) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Biotecnología | Universidad de Alicante. Departamento de Ingeniería Química |
Palabras clave: | Dioxin-like polychlorinated biphenyls | IVF | Embryo quality | Implantation | Clinical pregnancy | Live birth |
Área/s de conocimiento: | Biología Celular | Ingeniería Química |
Fecha de publicación: | 21-oct-2021 |
Editor: | Elsevier |
Cita bibliográfica: | Environmental Research. 2022, 206: 112248. https://doi.org/10.1016/j.envres.2021.112248 |
Resumen: | Dioxin-like polychlorinated biphenyls (DL-PCBs) are environmental pollutants that have been associated with impaired semen quality. However, research on the potential impact of paternal exposure to DL-PCBs and the risk of adverse pregnancy outcomes are limited. We examine the relationship between serum DL-PCB concentrations and IVF outcomes among 42 males seeking fertility treatment. Concentrations of 12 serum DL-PCBs were analyzed by high-resolution gas chromatography coupled to high-resolution mass spectrometry. Modified Poisson regressions, adjusted for confounders, were used to assess bivariate associations and to estimate risk ratios (RRs) between DL-PCBs and binary IVF outcomes. The median concentration (25th-75th percentiles) of the sum of the 12 DL-PCBs (∑DL-PCBs) obtained for the patients was 5.42 (3.78–7.78) ng/g lipid. No statistically significant association between DL-PCB levels and embryo quality was found. However, men with high serum PCB-77 concentrations present more probability of high-quality embryos (RR: 0.292; 95% CI: 0.090–0.942), whereas the opposite trend is observed for men with lower serum levels of PCB-156 (RR: 7.960; 95% CI: 1.020–62.100), who present increased odds of high-quality embryos. Serum concentrations of PCB-126 and PCB-114 were associated with decreased implantation rates (p < 0.05). Moreover, PCB-77 and ∑non-ortho PCBs were significantly associated with a lower likelihood of clinical pregnancy (p < 0.05). A lower likelihood of live birth was associated with higher levels of PCB-77, PCB-105, PCB-118, and recording significant differences for ∑non-ortho PCBs, ∑mono-ortho PCBs, and ∑DL-PCBs (p < 0.05). These findings suggest that paternal DL-PCB exposure before conception may be related to pregnancy endpoints. However, DL-PCB measurement were limited to male partners. Therefore, we propose that future studies with larger population sizes should include both maternal and paternal factors. |
Patrocinador/es: | This work was supported by the Chair in Human Fertility from the University of Alicante and the Ministry of Science and Innovation, Spain (project number PID 2019-105359RB-I00). |
URI: | http://hdl.handle.net/10045/118835 |
ISSN: | 0013-9351 (Print) | 1096-0953 (Online) |
DOI: | 10.1016/j.envres.2021.112248 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1016/j.envres.2021.112248 |
Aparece en las colecciones: | INV - REMAN - Artículos de Revistas INV - Grupo de Inmunología - Artículos de Revistas INV - I4CE - Artículos de Revistas |
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