Diagnostic Performance of Muscle Echo Intensity and Fractal Dimension for the Detection of Frailty Phenotype
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Título: | Diagnostic Performance of Muscle Echo Intensity and Fractal Dimension for the Detection of Frailty Phenotype |
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Autor/es: | Mirón Mombiela, Rebeca | Vucetic, Jelena | Monllor, Paloma | Cárdenas-Herrán, Jenny S. | Taltavull de La Paz, Paloma | Borrás, Consuelo |
Grupo/s de investigación o GITE: | Economía de la Vivienda y Sector Inmobiliario (ECOVISI) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Análisis Económico Aplicado |
Palabras clave: | Frailty | Ultrasound | Echo intensity | Fractal analysis | Muscle architecture |
Área/s de conocimiento: | Economía Aplicada |
Fecha de publicación: | 8-jul-2021 |
Editor: | SAGE Publications |
Cita bibliográfica: | Ultrasonic Imaging. 2021, 43(6): 337-352. https://doi.org/10.1177/01617346211029656 |
Resumen: | To determine the relationship between muscle echo intensity (EI) and fractal dimension (FD), and the diagnostic performance of both ultrasound parameters for the identification of frailty phenotype. A retrospective interpretation of ultrasound scans from a previous cohort (November 2014–February 2015) was performed. The sample included healthy participants <60 years old, and participants ≥60 divided into robust, pre-frail, and frail groups according to Fried frailty criteria. A region of interest of the rectus femoris from the ultrasound scan was segmented, and histogram function was applied to obtain EI. For fractal analysis, images were processed using two-dimensional box-counting techniques to calculate FD. Statistical analyses were performed with diagnostic performance tests. A total of 102 participants (mean age 63 ± 16, 57 men) were evaluated. Muscle fractal dimension correlated with EI (r = .38, p < .01) and showed different pattern in the scatter plots when participants were grouped by non-frail (control + robust) and frail (pre-frail + frail). The diagnostic accuracy for EI to categorize frailty was of 0.69 (95%CI: 0.59–0.78, p = .001), with high intra-rater (ICC: 0.98, 95%CI: 0.98–0.99); p < .001) and inter-rater (ICC: 0.89, 95%CI: 0.75–0.95; p < .001) reliability and low measurement error for both parameters (EI: −0.18, LOA95%: −10.8 to 10.5; FD: 0.00, LOA95%: −0.09 to 0.10) in arbitrary units. The ROC curve combining both parameters was not better than EI alone (p = .18). Muscle FD correlated with EI and showed different patterns according to frailty phenotype, with EI outperforming FD as a possible diagnostic tool for frailty. |
Patrocinador/es: | This work was supported by the Ministry of Economy and Competitiviness (PCIN-2017-117), the EU Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL INTIMIC-085) to CB. This research was also funded by the Young Researchers Grant awarded by the European Society of Musculoskeletal Radiology to RM. |
URI: | http://hdl.handle.net/10045/116455 |
ISSN: | 0161-7346 (Print) | 1096-0910 (Online) |
DOI: | 10.1177/01617346211029656 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © The Author(s) 2021 |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1177/01617346211029656 |
Aparece en las colecciones: | INV - ECOVISI - Artículos de Revistas |
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Archivo | Descripción | Tamaño | Formato | |
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Miron-Mombiela_etal_2021_UltrasonicImaging_final.pdf | Versión final (acceso restringido) | 1,98 MB | Adobe PDF | Abrir Solicitar una copia |
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