The heritability of insomnia: Systematic review and meta-analysis of twin studies
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Título: | The heritability of insomnia: Systematic review and meta-analysis of twin studies |
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Autor/es: | Madrid-Valero, Juan J. | Rubio-Aparicio, María | Gregory, Alice M. | Sánchez-Meca, Julio | Ordoñana, Juan R. |
Grupo/s de investigación o GITE: | Psicología Aplicada a la Salud y Comportamiento Humano (PSYBHE) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Psicología de la Salud |
Palabras clave: | Dizygotic | Genetics | Heritability | Insomnia | Monozygotic | Twins |
Área/s de conocimiento: | Psicología Básica | Personalidad, Evaluación y Tratamiento Psicológico |
Fecha de publicación: | ago-2021 |
Editor: | Elsevier |
Cita bibliográfica: | Sleep Medicine Reviews. 2021, 58: 101437. https://doi.org/10.1016/j.smrv.2021.101437 |
Resumen: | Twin studies have consistently found that genetic factors explain a substantial proportion of the variance for insomnia. However, studies vary widely in their heritability estimates. Therefore, this meta-analysis aimed to: 1) Estimate the mean heritability of insomnia; 2) Assess heterogeneity among twin studies of insomnia; and 3) Search and analyse characteristics of the studies (moderator variables) that may explain heterogeneity among estimates. For this purpose, separate meta-analyses were carried out for MZ and DZ correlations and for heritability estimates by assuming random-effects models. Thirteen independent samples were included in this meta-analysis. The heterogeneity index for heritability estimates was significant in both best fitting models (I2 = 98.77, P < .0001) and full models (I2 = 97.80, P < .0001). MZ correlations were higher (0.37; 95%CI: 0.31,.43) than DZ correlations (0.15; 95%CI: 0.12,.18). A mean heritability of 0.39 (95%CI: 0.32,.44) was found for insomnia. These results highlight the role of genetic factors in explaining differences among the population on insomnia and Emphasize heterogeneity among studies. Further research is needed to identify variables that could explain this heterogeneity. |
URI: | http://hdl.handle.net/10045/112689 |
ISSN: | 1087-0792 (Print) | 1532-2955 (Online) |
DOI: | 10.1016/j.smrv.2021.101437 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2021 Elsevier Ltd. |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1016/j.smrv.2021.101437 |
Aparece en las colecciones: | INV - PSYBHE - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
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Madrid-Valero_etal_2021_SleepMedRev_final.pdf | Versión final (acceso restringido) | 1,13 MB | Adobe PDF | Abrir Vista previa |
Madrid-Valero_etal_2021_SleepMedRev_preprint.pdf | Preprint (acceso abierto) | 453,88 kB | Adobe PDF | Abrir Vista previa |
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