Biomagnification and body distribution of ivermectin in dung beetles
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Título: | Biomagnification and body distribution of ivermectin in dung beetles |
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Autor/es: | Verdú, José R. | Cortez, Vieyle | Ortiz, Antonio J. | Lumaret, Jean-Pierre | Lobo, Jorge M. | Sánchez-Piñero, Francisco |
Grupo/s de investigación o GITE: | Biodiversidad y Biotecnología aplicadas a la Biología de la Conservación |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Ciencias Ambientales y Recursos Naturales | Universidad de Alicante. Centro Iberoamericano de la Biodiversidad |
Palabras clave: | Dung beetles | Biomagnification | Body distribution | Ivermectin |
Área/s de conocimiento: | Zoología |
Fecha de publicación: | 3-jun-2020 |
Editor: | Springer Nature |
Cita bibliográfica: | Scientific Reports. 2020, 10: 9073. doi:10.1038/s41598-020-66063-0 |
Resumen: | A terrestrial test system to investigate the biomagnification potential and tissue-specific distribution of ivermectin, a widely used parasiticide, in the non-target dung beetle Thorectes lusitanicus (Jekel) was developed and validated. Biomagnification kinetics of ivermectin in T. lusitanicus was investigated by following uptake, elimination, and distribution of the compound in dung beetles feeding on contaminated faeces. Results showed that ivermectin was biomagnified in adults of T. lusitanicus when exposed to non-lethal doses via food uptake. Ivermectin was quickly transferred from the gut to the haemolymph, generating a biomagnification factor (BMFk) three times higher in the haemolymph than in the gut after an uptake period of 12 days. The fat body appeared to exert a major role on the biomagnification of ivermectin in the insect body, showing a BMFk 1.6 times higher than in the haemolymph. The results of this study highlight that the biomagnification of ivermectin should be investigated from a global dung-based food web perspective and that the use of these antiparasitic substances should be monitored and controlled on a precautionary basis. Thus, we suggest that an additional effort be made in the development of standardised regulatory recommendations to guide biomagnification studies in terrestrial organisms, but also that it is necessary to adapt existing methods to assess the effects of such veterinary medical products. |
Patrocinador/es: | Financial support was provided by the project CGL2015-68207-R of the Secretaría de Estado de Investigación–Ministerio de Economía y Competitividad. |
URI: | http://hdl.handle.net/10045/107308 |
ISSN: | 2045-2322 |
DOI: | 10.1038/s41598-020-66063-0 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1038/s41598-020-66063-0 |
Aparece en las colecciones: | INV - BBaBC - Artículos de Revistas |
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